PMID- 20015003
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20191027
IS  - 1875-5992 (Electronic)
IS  - 1871-5206 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Jan
TI  - Application of biological study for met expression to cancer therapy.
PG  - 58-63
AB  - Metastasization is an undesirable process in cancer development and may represent 
      the most critical factor in deciding patient prognosis. Organ specificity of the 
      metastasis process suggests the importance of the paracrine factors: one of the 
      most potent paracrine regulators of tumor cell migration is hepatocyte growth 
      factor/scatter factor (HGF/SF). Because the liver-specific growth factor is HGF, 
      its receptor c-Met expression might play a critical role in metastasization to 
      the liver. Activation of HGF/c-Met signaling has been shown to promote cancer 
      cell invasiveness and trigger metastasis though direct involvement of the 
      angiogenic pathway. Given the importance of aberrant HGF/c-Met signaling, several 
      different therapeutic strategies aimed at inhibiting the pathway have been 
      developed and are currently being evaluated in clinical trials. Among these 
      agents, NK4 and AM102 were introduced as HGF inhibitors, and PHA-665752 and 
      Su11274 as c-Met inhibitors and are under study in clinical trials. Further, 
      clinical experience-based study to apply the accumulation of biological knowledge 
      concerning HGF/c-Met to the surgical field is presented.
FAU - Osada, Shinji
AU  - Osada S
AD  - Gifu University School of Medicine, Japan. sting@gifu-u.ac.jp
FAU - Yoshida, Kazuhiro
AU  - Yoshida K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Anticancer Agents Med Chem
JT  - Anti-cancer agents in medicinal chemistry
JID - 101265649
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Hepatocyte Growth Factor/antagonists & inhibitors/metabolism
MH  - Humans
MH  - Neoplasms/*drug therapy/surgery
MH  - Proto-Oncogene Proteins c-met/*metabolism
RF  - 58
EDAT- 2009/12/18 06:00
MHDA- 2010/06/02 06:00
CRDT- 2009/12/18 06:00
PHST- 2009/10/02 00:00 [received]
PHST- 2009/11/17 00:00 [accepted]
PHST- 2009/12/18 06:00 [entrez]
PHST- 2009/12/18 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
AID - ACA-MC-51 [pii]
AID - 10.2174/1871520611009010058 [doi]
PST - ppublish
SO  - Anticancer Agents Med Chem. 2010 Jan;10(1):58-63. doi: 
      10.2174/1871520611009010058.