PMID- 20015326
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20221207
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 65
IP  - 7
DP  - 2010 Jul
TI  - Relationship of serum cholesterol levels to atopy in the US population.
PG  - 859-64
LID - 10.1111/j.1398-9995.2009.02287.x [doi]
AB  - BACKGROUND: Cholesterol promotes Th2 immunity and allergic inflammation in 
      rodents; whether this occurs in humans is unclear. Reports of both direct and 
      inverse associations between serum cholesterol and atopy in different populations 
      suggest that race and/or other demographic variables may modify these 
      relationships. AIMS OF THE STUDY: To determine the relationships between levels 
      of three serum cholesterol measures [total cholesterol (TC), high density 
      lipoprotein-cholesterol (HDL-C), and non-HDL-C] and atopy in a sample 
      representative of the US population. METHODS: Cross-sectional study of 6854 
      participants aged > or =6 years from the 2005-2006 National Health and Nutrition 
      Examination Survey. RESULTS: In the overall population, adjusted odds ratios 
      (AORs) per two-standard deviation increase in TC and non-HDL-C for biochemical 
      atopy (defined as > or =1 allergen-specific IgE to 19 allergens) were 1.17 [95% 
      confidence interval (CI), 1.00-1.38] and 1.19 (95% CI, 1.03-1.39), respectively. 
      Interactions by race were noted for the two relationships (interaction P = 0.004 
      and P = 0.009, respectively) with non-Hispanic Whites (NHWs) having direct 
      relationships [TC: AOR 1.27 (95% CI, 1.03-1.57); non-HDL-C: AOR 1.27 (95% CI, 
      1.03-1.56)] and non-Hispanic Blacks (NHBs) inverse relationships [TC: AOR 0.77 
      (95% CI, 0.62-0.95); non-HDL-C: AOR 0.86 (95% CI, 0.69-1.08)]. The adjusted 
      HDL-C-atopy relationship was nonsignificant for NHWs and inverse for NHBs [AOR 
      0.77 (95% CI, 0.61-0.96)]. Relationships were independent of body mass index and 
      serum C-reactive protein and unmodified by corticosteroid or statin usage. 
      Results were similar using current hay fever/allergy as the atopy outcome. 
      CONCLUSIONS: There are marked inter-racial differences in the relationship 
      between serum cholesterol and atopy in the US population.
FAU - Fessler, M B
AU  - Fessler MB
AD  - Laboratory of Respiratory Biology, National Institute of Environmental Health 
      Sciences, National Institutes of Health, Department of Health and Human Services, 
      Research Triangle Park, NC 27709, USA. fesslerm@niehs.nih.gov
FAU - Jaramillo, R
AU  - Jaramillo R
FAU - Crockett, P W
AU  - Crockett PW
FAU - Zeldin, D C
AU  - Zeldin DC
LA  - eng
GR  - Z01 ES102005/ImNIH/Intramural NIH HHS/United States
GR  - ZIA ES102005-07/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20091216
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Black People
MH  - Child
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/*blood
MH  - Cholesterol, LDL/*blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*blood/*ethnology
MH  - Male
MH  - Prevalence
MH  - White People
MH  - Young Adult
PMC - PMC4045486
MID - NIHMS555326
EDAT- 2009/12/18 06:00
MHDA- 2010/10/28 06:00
PMCR- 2014/06/04
CRDT- 2009/12/18 06:00
PHST- 2009/12/18 06:00 [entrez]
PHST- 2009/12/18 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
PHST- 2014/06/04 00:00 [pmc-release]
AID - ALL2287 [pii]
AID - 10.1111/j.1398-9995.2009.02287.x [doi]
PST - ppublish
SO  - Allergy. 2010 Jul;65(7):859-64. doi: 10.1111/j.1398-9995.2009.02287.x. Epub 2009 
      Dec 16.