PMID- 20016170
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20091217
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 126
IP  - 1-2
DP  - 2009
TI  - Analysis using sperm-FISH of a putative interchromosomal effect in boars carrying 
      reciprocal translocations.
PG  - 194-201
LID - 10.1159/000245920 [doi]
AB  - The occurrence of interchromosomal effects (ICE) in reciprocal translocation 
      carriers still remains contradictory in the human literature. We used the pig as 
      an animal model to investigate whether the structure of the reciprocal 
      translocations as well as the size and/or type of the chromosomes not involved in 
      the rearrangement may influence the occurrence and the extent of ICE. Analyses of 
      chromosomal sperm content by fluorescence in situ hybridization (FISH) using 
      whole-chromosome painting probes for 7 chromosomes (1, 10, 11, 13, 18, X and Y) 
      were carried out on sperm samples of 2 boars with normal semen parameters 
      carrying different balanced reciprocal translocations: 38, XY, t(3;15)(q27;q13) 
      or 38, XY, t(12;14)(q13;q21). One fertile boar with normal karyotype was also 
      studied as a control. Aneuploidy rates for the 7 chromosomes were estimated by 
      scoring 10,000 to 20,000 spermatozoa for each probe combination. No significant 
      ICE was found except for chromosome 1 in the case of the t(3;15) translocation. 
      Even if statistically significant, this ICE remained very weak and should have 
      very little impact on the reproductive performance of the carrier boar. The size 
      and/or type of chromosomes not involved in the translocation do not seem to have 
      a major influence on the occurrence of ICE. The structure of the translocation 
      could play a role, but complementary studies should be carried out to confirm 
      this assumption.
CI  - (c) 2009 S. Karger AG, Basel.
FAU - Bonnet-Garnier, A
AU  - Bonnet-Garnier A
AD  - UMR 444 Genetique Cellulaire, INRA-ENVT, Toulouse, France. 
      amelie.bonnet-garnier@jouy.inra.fr
FAU - Guardia, S
AU  - Guardia S
FAU - Pinton, A
AU  - Pinton A
FAU - Ducos, A
AU  - Ducos A
FAU - Yerle, M
AU  - Yerle M
LA  - eng
PT  - Journal Article
DEP - 20091209
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
SB  - IM
MH  - Animals
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Spectral Karyotyping
MH  - Spermatozoa/*metabolism
MH  - Swine/*genetics
MH  - *Translocation, Genetic
EDAT- 2009/12/18 06:00
MHDA- 2010/01/12 06:00
CRDT- 2009/12/18 06:00
PHST- 2009/06/11 00:00 [accepted]
PHST- 2009/12/18 06:00 [entrez]
PHST- 2009/12/18 06:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
AID - 000245920 [pii]
AID - 10.1159/000245920 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2009;126(1-2):194-201. doi: 10.1159/000245920. Epub 2009 
      Dec 9.