PMID- 20016199
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20211203
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 152
IP  - 2
DP  - 2010
TI  - Human leukocyte antigen (DR1)-DQB1*0501 and (DR15)-DQB1*0602 haplotypes are 
      associated with humoral responses to early food allergens in children.
PG  - 169-77
LID - 10.1159/000265538 [doi]
AB  - BACKGROUND: Infants' immunological responses to cow's milk (CM) proteins, which 
      in 2-3% result in allergy, may partially depend on genetic factors. We evaluated 
      whether genes with immunological functions, i.e. human leukocyte antigen (HLA) 
      II, the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) and 
      filaggrin, modulate immune responses to dietary antigens. METHODS: We analyzed 14 
      HLA class II haplotypes, the PTPN22 1858 SNP (R620W allele) and 5 known filaggrin 
      null mutations from blood samples of 87 patients with CM allergy (CMA) and 76 
      control subjects (age 8.0-9.3 years). Serum levels of IgA, IgG, IgG1 and IgG4 
      antibodies to beta-lactoglobulin, alpha-casein and ovalbumin were measured with 
      enzyme-linked immunosorbent assay, levels of IgE antibodies to CM, ovalbumin and 
      birch with UniCap (Phadia, Uppsala, Sweden). RESULTS: In children with CMA, the 
      HLA (DR15)-DQB1*0602 haplotype was associated with high levels of 
      beta-lactoglobulin-specific total IgG (p < 0.001) and IgG4 (p < 0.001) and 
      alpha-casein-specific total IgG (p = 0.003) and IgG4 (p = 0.002), but not among 
      control subjects. (DR1/10)-DQB1*0501 was associated with lower levels of 
      beta-lactoglobulin-specific total IgG (p < 0.001) and IgG4 (p < 0.001), 
      ovalbumin-specific total IgG (p = 0.002) and IgG4 (p < 0.001), particularly in 
      control subjects (p < 0.001). Six children with eczema (3 with CMA) had the 
      filaggrin mutation del22824. PTPN22 was not associated with specific antibody 
      responses or CMA. CONCLUSION: The HLA II, but not PTPN22 or filaggrin, genotype 
      modulates humoral responses to early food allergens, whereas none of these genes 
      was associated with CMA.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Savilahti, Emma M
AU  - Savilahti EM
AD  - Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. 
      erkki.savilahti@hus.fi
FAU - Ilonen, Jorma
AU  - Ilonen J
FAU - Kiviniemi, Minna
AU  - Kiviniemi M
FAU - Saarinen, Kristiina M
AU  - Saarinen KM
FAU - Vaarala, Outi
AU  - Vaarala O
FAU - Savilahti, Erkki
AU  - Savilahti E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091216
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Caseins)
RN  - 0 (FLG protein, human)
RN  - 0 (Filaggrin Proteins)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (Lactoglobulins)
RN  - 0 (Milk Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 3.1.3.48 (PTPN22 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 22)
SB  - IM
MH  - Animals
MH  - Betula/immunology
MH  - Caseins/immunology
MH  - Cattle
MH  - Chickens
MH  - Child
MH  - Dermatitis, Atopic/genetics
MH  - Filaggrin Proteins
MH  - Finland
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Haplotypes/*immunology
MH  - Humans
MH  - Immunity, Humoral/*genetics/immunology
MH  - Immunoglobulin A/blood/immunology
MH  - Immunoglobulin E/blood/immunology
MH  - Immunoglobulin G/blood/immunology
MH  - Intermediate Filament Proteins/genetics
MH  - Lactoglobulins/immunology
MH  - Milk Hypersensitivity/*genetics/immunology
MH  - Milk Proteins/immunology
MH  - Ovalbumin/immunology
MH  - Pollen/immunology
MH  - Polymorphism, Genetic/immunology
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics
EDAT- 2009/12/18 06:00
MHDA- 2010/06/25 06:00
CRDT- 2009/12/18 06:00
PHST- 2009/03/23 00:00 [received]
PHST- 2009/08/28 00:00 [accepted]
PHST- 2009/12/18 06:00 [entrez]
PHST- 2009/12/18 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - 000265538 [pii]
AID - 10.1159/000265538 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2010;152(2):169-77. doi: 10.1159/000265538. Epub 2009 
      Dec 16.