PMID- 20016853
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20211020
IS  - 0214-0934 (Print)
IS  - 0214-0934 (Linking)
VI  - 22
IP  - 8
DP  - 2009 Oct
TI  - Dendritic cell modulation as a new interventional approach for the treatment of 
      asthma.
PG  - 445-51
AB  - Dendritic cells (DCs) have a central role in the immune system, as they control 
      the adaptive immune response and mediate both protective immunity and the 
      maintenance of immune tolerance to self antigens. In this review, we will 
      summarize the recent advances regarding the subsets of DCs and how they regulate 
      the differentiation of naive CD4(+) T cells towards different populations of T 
      helper cells. We will particularly describe the role of DCs in the development 
      and regulation of allergic diseases and asthma, and discuss the capacity of DCs 
      to induce proallergenic Th2 cells versus regulatory T cells. Undoubtedly, 
      tolerogenic DCs play a crucial role in the induction of regulatory cells. 
      Understanding the biology of these cells will help us design novel strategies to 
      cure or prevent allergic diseases and asthma.
CI  - Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved.
FAU - Lombardi, Vincent
AU  - Lombardi V
AD  - University of Southern California, Keck School of Medicine, Department of 
      Molecular Microbiology and Immunology, Los Angeles, California 90033-9605, USA.
FAU - Akbari, Omid
AU  - Akbari O
LA  - eng
GR  - R01 AI066020-01A2/AI/NIAID NIH HHS/United States
GR  - R01 AI066020-03/AI/NIAID NIH HHS/United States
GR  - R01 AI066020/AI/NIAID NIH HHS/United States
GR  - R01 AI066020-02/AI/NIAID NIH HHS/United States
GR  - R01 AI066020-04/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Drug News Perspect
JT  - Drug news & perspectives
JID - 8809164
SB  - IM
MH  - Animals
MH  - Asthma/drug therapy/*immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/*immunology
MH  - Drug Delivery Systems
MH  - Humans
MH  - Hypersensitivity/drug therapy/*immunology
MH  - Immune Tolerance
MH  - T-Lymphocytes, Helper-Inducer/immunology
PMC - PMC2845716
MID - NIHMS181846
EDAT- 2009/12/18 06:00
MHDA- 2010/03/17 06:00
PMCR- 2010/03/25
CRDT- 2009/12/18 06:00
PHST- 2009/12/18 06:00 [entrez]
PHST- 2009/12/18 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
PHST- 2010/03/25 00:00 [pmc-release]
AID - 4631 [pii]
PST - ppublish
SO  - Drug News Perspect. 2009 Oct;22(8):445-51.