PMID- 20017299
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 26
IP  - 4
DP  - 2009 Aug
TI  - [DRB1 * 1454: the common allele of human leukocyte antigen-DRB1 * 14 in Chinese 
      Han populations].
PG  - 379-82
AB  - OBJECTIVE: To investigate and compare the distribution of HLA-DRB1 * 14 alleles 
      between the southern and northern Chinese Han populations. METHODS: Human 
      leukocyte antigen (HLA)-DRB1 alleles of 436 southern and 713 northern Chinese Han 
      bone marrow volunteers were genotyped by polymerase chain reaction 
      (PCR)-sequence-based-typing (SBT) method, among them the DRB1 * 1401/1439/1454 
      ambiguous allele pairs were identified using DRB1 * 14 high-resolution 
      PCR-sequence specific primer (SSP) kits. Also, the clinic samples previously 
      reported as DRB1 * 1401 were re-genotyped using the same PCR-SSP kits. The 
      allelic distribution of DRB1 * 14 in southern and northern Chinese Han population 
      were compared by chi-square test method. RESULTS: Eighty-one ambiguous allele 
      pairs of DRB1 * 1401/1439/1454 and 54 clinic samples previously reported as DRB1 
      * 1401 were all identified as DRB1 * 1454. Among the 436 Southern Han donors, six 
      subtypes of DRB1 * 14 allele were observed including DRB1 * 1454 (69.57%), DRB1 * 
      1402 (1.45%), DRB1* 1403 (1.45%), DRB1 * 1404 (4.35%), DRB1 * 1405 (20.29%) and 
      DRB1 * 1407 (2.90%). In the 713 northern Han donors, a total of seven subtypes 
      were observed including DRB1 * 1454 (35.48%), DRB1 * 1403 (12.90%), DRB1 * 1404 
      (6.45%), DRB1 * 1405 (37.63%), DRB1 * 1407 (4.30%), DRB1 * 1411 (1.08%) and DRB1 
      * 1412 (2.15%). CONCLUSION: DRB1 * 1454 and DRB1 * 1405 were the most common 
      alleles of HLA-DRB1 * 14 in Chinese Han populations. The distribution of HLA-DRB1 
      * 14 differ significantly between the southern and northern Chinese Han 
      population, while DRB1 * 1405 showed similar distribution pattern in the two 
      populations but DRB1 * 1454 had higher frequency in southern than in northern 
      Chinese Han population.
FAU - Cheng, Liang-hong
AU  - Cheng LH
AD  - Immunogenetics and Histocompatibility Testing Laboratory, Shenzhen Blood Center, 
      Shenzhen, Guangdong, 518035 P.R. China. chenglh99@yahoo.com.cn
FAU - Jin, Shi-zheng
AU  - Jin SZ
FAU - Zou, Hong-yan
AU  - Zou HY
FAU - Gao, Su-qin
AU  - Gao SQ
FAU - Li, Zhen
AU  - Li Z
FAU - Wang, Da-ming
AU  - Wang DM
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asian People/ethnology/*genetics
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
EDAT- 2009/12/19 06:00
MHDA- 2010/01/13 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Aug;26(4):379-82.