PMID- 20017313
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20091218
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 26
IP  - 4
DP  - 2009 Aug
TI  - [Trisomy 8 in chronic lymphocytic leukemia].
PG  - 443-5
AB  - OBJECTIVE: To investigate the incidence of trisomy 8 in chronic lymphocytic 
      leukemia (CLL) and its significance in prognosis. METHODS: A panel of probes and 
      fluorescence in situ hybridization (FISH) were used to detect trisomy 8 in 151 
      CLL patients combined with chromosome karyotype analysis. RESULTS: There were 2 
      patients (1.3%) with trisomy 8 in the 151 CLL patients, and the number of trisomy 
      8 cells was 8% and 10% respectively. The karyotypes were 
      47,XY,+8[2]/49,XY,+14,+20,+21[2]/ 46,XY[16], and 47,XX,+8[2]/46,XX[18], 
      respectively. CONCLUSION: Trisomy 8 was rare in CLL, and its significance in 
      prognosis of CLL still remains unknown.
FAU - Cao, Xin
AU  - Cao X
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, 210029 P.R. China.
FAU - Xu, Wei
AU  - Xu W
FAU - Liu, Qiong
AU  - Liu Q
FAU - Zhu, Dan-xia
AU  - Zhu DX
FAU - Qiao, Chun
AU  - Qiao C
FAU - Wu, Yu-jie
AU  - Wu YJ
FAU - Qiu, Hong-xia
AU  - Qiu HX
FAU - Li, Jian-yong
AU  - Li JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - *Trisomy
EDAT- 2009/12/19 06:00
MHDA- 2010/01/13 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Aug;26(4):443-5.