PMID- 20017315
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 26
IP  - 4
DP  - 2009 Aug
TI  - [Association of the D358A polymorphism of IL6R gene with type 2 diabetes in Hubei 
      Han Chinese].
PG  - 452-6
AB  - OBJECTIVE: To investigate the association of the D358A polymorphism of 
      interleukin 6 receptor( IL6R ) gene with type 2 diabetes mellitus (T2DM) in Hubei 
      Han Chinese. METHODS: The single nucleotide polymorphism D358A of the IL6R gene 
      was genotyped in 581 T2DM patients and 353 healthy controls. Meta-analysis was 
      used to assess the reported association between the IL6R D358A and T2DM. RESULTS: 
      The frequencies of CC genotype and C allele of IL6R D358A in the patients were 
      significantly lower than those in controls (CC: 13.4% vs. 20.7%, P=0.003; C: 
      36.0% vs. 41.8%, P=0.012), with the CC genotype being a protective factor for 
      T2DM (OR=0.595, P=0.003). Logistic regression analysis suggested that the CC 
      genotype was significantly associated with T2DM after adjusted for age, sex, 
      blood pressure and obesity (OR=0.615, 95% CI: 0.407- 0.928, P=0.021). 
      Meta-analysis of 6 studies indicated that there existed genetic heterogeneity, 
      and the CC genotype was associated with lower risk of T2DM (P=0.009, OR=0.64, 95% 
      CI: 0.48-0.85). CONCLUSION: IL6R is a susceptibility gene for T2DM in Han Chinese 
      population of Hubei, and the CC genotype may serve as a genetic protective factor 
      of T2DM.
FAU - Zhang, Shuang
AU  - Zhang S
AD  - School of Life Sciences, Central China Normal University, Wuhan, Hubei, 430079 
      P.R. China.
FAU - Zhang, Ping
AU  - Zhang P
FAU - Huang, Qing-yang
AU  - Huang QY
LA  - chi
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (IL6R protein, human)
RN  - 0 (Receptors, Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/ethnology/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics
MH  - Female
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin-6/*genetics
MH  - White People/genetics
EDAT- 2009/12/19 06:00
MHDA- 2010/01/13 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Aug;26(4):452-6.