PMID- 20017457
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20161026
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 110
IP  - 10
DP  - 2009
TI  - Serum and synovial fluid concentrations of CCL2 (MCP-1) chemokine in patients 
      suffering rheumatoid arthritis and osteoarthritis reflect disease activity.
PG  - 641-6
AB  - OBJECTIVE: To determine serum and synovial fluid (SF) concentrations of monocyte 
      chemoattractant protein-1 (MCP-1) or CCL2 chemokine, in patients suffering (RA) 
      and osteoarthritis (OA) and to correlate the values to disease activity, and 
      other patient- and disease-related parameters. METHODS: The CCL-2/MCP-1 chemokine 
      (CK) was measured in serum and SF of 30 RA and 15 OA patients using specific and 
      very sensitive ELISA assay. RESULTS: The CCL2/MCP-1 CK was found in increased 
      amounts in SF compared to serum (p < 0.001) and in RA compared to OA patients (p 
      < 0.001). The values were significantly greater in RA patients with more active 
      disease. Greater mean SF concentrations were observed in older RA patients, in 
      patients with longer duration of RA disease and in those who had been treated 
      with methotrexate. Also positive correlation was found between RA SF 
      concentrations and SF leukocyte numbers (r = 0.497, p < 0.05). CONCLUSIONS: The 
      SF and serum CCL2/MCP-1 concentrations are significantly greater in RA than in OA 
      and in hda-RA than in mda-RA; increased SF over serum concentrations suggest that 
      CCL2/MCP-1 is mainly produced locally by activated cells where it may exacerbate 
      and sustain inflammation by attracting proinflammatory leukocytes, predominantly 
      monocytes (Tab. 1, Fig. 2, Ref. 50). Full Text (Free, PDF) www.bmj.sk.
FAU - Stankovic, A
AU  - Stankovic A
AD  - Institute for Prevention and Treatment of Rheumatic Diseases, Niska banja, 
      Serbia. ackana@junis.ni.ac.yu
FAU - Slavic, V
AU  - Slavic V
FAU - Stamenkovic, B
AU  - Stamenkovic B
FAU - Kamenov, B
AU  - Kamenov B
FAU - Bojanovic, M
AU  - Bojanovic M
FAU - Mitrovic, D R
AU  - Mitrovic DR
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/blood/*metabolism/pathology
MH  - Chemokine CCL2/*analysis/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis/blood/*metabolism/pathology
MH  - Synovial Fluid/*chemistry
MH  - Young Adult
EDAT- 2009/12/19 06:00
MHDA- 2010/01/13 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
PST - ppublish
SO  - Bratisl Lek Listy. 2009;110(10):641-6.