PMID- 20018024
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1753-6561 (Electronic)
IS  - 1753-6561 (Linking)
VI  - 3 Suppl 7
IP  - Suppl 7
DP  - 2009 Dec 15
TI  - On the association between rheumatoid arthritis and classical HLA class I and 
      class II alleles predicted from single-nucleotide polymorphism data.
PG  - S33
AB  - Using single-nucleotide polymorphisms (SNPs), we sought to predict classical 
      class I and class II human leukocyte antigen (HLA) alleles, and test for their 
      associations with rheumatoid arthritis (RA) in the North American Rheumatoid 
      Arthritis Consortium sample of cases and controls, genotyped on the Illumina 
      HumanHap550 BeadChip. We use publicly available databases of SNP data and HLA 
      data to find SNPs or SNP-haplotypes to be used as surrogates for each HLA allele. 
      To reduce the confounding effects of linkage disequilibrium with the HLA-DRB1 
      locus, we tested for the association conditional on the presence or absence of a 
      shared epitope allele on the same haplotype as the target HLA allele. Using SNP 
      surrogates, we find that components of the DQ8 serotype (DQA1*0301:DQB1*0302) are 
      associated with RA, irrespective of the presence or absence of a shared epitope 
      allele on their respective haplotypes. Knowledge of the haplotype structure in 
      the HLA region is still necessary for better interpretation of the results.
FAU - Lemire, Mathieu
AU  - Lemire M
AD  - Ontario Institute for Cancer Research, 101 College Street, Suite 800, MaRS 
      Centre, South Tower, Toronto, ON M5G0A3 Canada. mathieu.lemire@oicr.on.ca.
LA  - eng
GR  - R01 GM031575/GM/NIGMS NIH HHS/United States
GR  - R01 GM031575-28/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20091215
PL  - England
TA  - BMC Proc
JT  - BMC proceedings
JID - 101316936
PMC - PMC2795931
EDAT- 2009/12/19 06:00
MHDA- 2009/12/19 06:01
PMCR- 2009/12/15
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2009/12/19 06:01 [medline]
PHST- 2009/12/15 00:00 [pmc-release]
AID - 1753-6561-3-S7-S33 [pii]
AID - 10.1186/1753-6561-3-s7-s33 [doi]
PST - epublish
SO  - BMC Proc. 2009 Dec 15;3 Suppl 7(Suppl 7):S33. doi: 10.1186/1753-6561-3-s7-s33.