PMID- 20018074
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1753-6561 (Electronic)
IS  - 1753-6561 (Linking)
VI  - 3 Suppl 7
IP  - Suppl 7
DP  - 2009 Dec 15
TI  - Identifying rheumatoid arthritis susceptibility genes using high-dimensional 
      methods.
PG  - S79
AB  - Although several genes (including a strong effect in the human leukocyte antigen 
      (HLA) region) and some environmental factors have been implicated to cause 
      susceptibility to rheumatoid arthritis (RA), the etiology of the disease is not 
      completely understood. The ability to screen the entire genome for association to 
      complex diseases has great potential for identifying gene effects. However, the 
      efficiency of gene detection in this situation may be improved by methods 
      specifically designed for high-dimensional data. The aim of this study was to 
      compare how three different statistical approaches, multifactor dimensionality 
      reduction (MDR), random forests (RF), and an omnibus approach, worked in 
      identifying gene effects (including gene-gene interaction) associated with RA. We 
      developed a test set of genes based on previous linkage and association findings 
      and tested all three methods. In the presence of the HLA shared-epitope factor, 
      other genes showed weaker effects. All three methods detected SNPs in PTPN22 and 
      TRAF1-C5 as being important. But we did not detect any new genes in this study. 
      We conclude that the three high-dimensional methods are useful as an initial 
      screening for gene associations to identify promising genes for further modeling 
      and additional replication studies.
FAU - Liang, Xueying
AU  - Liang X
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National 
      Institutes of Health, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA. 
      liangx2@mail.nih.gov.
FAU - Gao, Ying
AU  - Gao Y
FAU - Lam, Tram K
AU  - Lam TK
FAU - Li, Qizhai
AU  - Li Q
FAU - Falk, Cathy
AU  - Falk C
FAU - Yang, Xiaohong R
AU  - Yang XR
FAU - Goldstein, Alisa M
AU  - Goldstein AM
FAU - Goldin, Lynn R
AU  - Goldin LR
LA  - eng
GR  - R01 GM031575/GM/NIGMS NIH HHS/United States
GR  - R01 GM031575-28/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20091215
PL  - England
TA  - BMC Proc
JT  - BMC proceedings
JID - 101316936
PMC - PMC2795981
EDAT- 2009/12/19 06:00
MHDA- 2009/12/19 06:01
PMCR- 2009/12/15
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2009/12/19 06:01 [medline]
PHST- 2009/12/15 00:00 [pmc-release]
AID - 1753-6561-3-S7-S79 [pii]
AID - 10.1186/1753-6561-3-s7-s79 [doi]
PST - epublish
SO  - BMC Proc. 2009 Dec 15;3 Suppl 7(Suppl 7):S79. doi: 10.1186/1753-6561-3-s7-s79.