PMID- 20018804
OWN - NLM
STAT- MEDLINE
DCOM- 20100204
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 140
IP  - 2
DP  - 2010 Feb
TI  - The natural 13C abundance of plasma glucose is a useful biomarker of recent 
      dietary caloric sweetener intake.
PG  - 333-7
LID - 10.3945/jn.109.114777 [doi]
AB  - There is a need for objective biomarkers of dietary intake, because 
      self-reporting is often subject to bias. We tested the validity of a biomarker 
      for the fraction of dietary carbohydrate (CHO) from cane sugar and high fructose 
      corn syrup (C(4) sugars) using natural (13)C abundance of plasma glucose. In a 
      randomized, single-blinded, crossover design, 5 participants consumed 3 
      weight-maintaining diets for 7 d, with a 2-wk washout between diet periods. Diets 
      differed in the fraction of total CHO energy from C(4) sugars (5, 16, or 32%). 
      During each diet period, blood samples were drawn at hours 0800 and 1600 on d 1, 
      3, and 5 and at 0800, 1000, 1200, 1400, and 1600 on d 7. The delta(13)C abundance 
      of plasma glucose was analyzed via GC- isotope ratio MS. Within each diet period, 
      delta(13)C abundance of the 0800 fasting glucose did not change from baseline 
      with increasing time during a diet period; however, there was a strong positive 
      correlation (R(2) = 0.89) between delta(13)C abundance of the glucose 
      concentration at 1000 on d 7 and the percent of breakfast CHO from C(4) sugars. 
      Also, delta(13)C abundance of the combined plasma glucose samples on d 7 
      demonstrated a strong positive correlation (R(2) = 0.90) with the percent of 
      total daily CHO from C(4) sugars. The natural delta(13)C abundance of 
      postprandial plasma glucose relative to dietary C(4) CHO content was a valid 
      biomarker for contributions of C(4) caloric sweeteners from the previous meal.
FAU - Cook, Chad M
AU  - Cook CM
AD  - University of Wisconsin, Interdepartmental Graduate Program in Nutritional 
      Science, Madison, WI 53706, USA.
FAU - Alvig, Amy L
AU  - Alvig AL
FAU - Liu, Yu Qiu David
AU  - Liu YQ
FAU - Schoeller, Dale A
AU  - Schoeller DA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Validation Study
DEP - 20091216
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Carbon Isotopes)
RN  - 0 (Dietary Sucrose)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/*analysis/chemistry
MH  - Carbon Isotopes/*analysis
MH  - Cross-Over Studies
MH  - *Diet
MH  - Dietary Sucrose/*administration & dosage/blood
MH  - *Energy Intake
MH  - Female
MH  - Humans
MH  - Male
MH  - Postprandial Period
MH  - Saccharum
MH  - Single-Blind Method
MH  - Young Adult
MH  - Zea mays
EDAT- 2009/12/19 06:00
MHDA- 2010/02/05 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/02/05 06:00 [medline]
AID - S0022-3166(22)06968-1 [pii]
AID - 10.3945/jn.109.114777 [doi]
PST - ppublish
SO  - J Nutr. 2010 Feb;140(2):333-7. doi: 10.3945/jn.109.114777. Epub 2009 Dec 16.