PMID- 2001978
OWN - NLM
STAT- MEDLINE
DCOM- 19910412
LR  - 20190903
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 30
IP  - 1
DP  - 1991 Jan
TI  - B27-bearing HLA haplotypes in rheumatoid arthritis: characterization in Finnish 
      patients.
PG  - 7-10
AB  - The frequency of human leukocyte antigen (HLA)-B27 has been found to be increased 
      in rheumatoid arthritis (RA) in Finland and marginally also in some other 
      populations. In the present study HLA-B27-bearing haplotypes in RA patients were 
      found to carry DR1 and DR4 genes more often than do B27 haplotypes in control 
      population. B27;DR4,DW14;DQw7 was a typical B27-DR4 haplotype whereas DR4 in the 
      majority of other haplotypes occurs with Dw4 and DQw8 genes. The result indicates 
      that the B27 association with RA is not independent of DR1 and DR4, but whether 
      the B27;DR4;DQw7 haplotype subjects a person to a higher disease risk than do 
      other DR4 haplotypes, or is associated with a more severe course of the disease, 
      remains to be investigated.
FAU - Ilonen, J
AU  - Ilonen J
AD  - Department of Medical Microbiology, University of Oulu, Finland.
FAU - Hakala, M
AU  - Hakala M
FAU - Reijonen, H
AU  - Reijonen H
FAU - Tiilikainen, A
AU  - Tiilikainen A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Arthritis, Rheumatoid/genetics/*immunology
MH  - Gene Frequency
MH  - HLA-B27 Antigen/*genetics
MH  - HLA-DR Antigens/genetics
MH  - Haplotypes
MH  - Humans
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0198-8859(91)90063-F [pii]
AID - 10.1016/0198-8859(91)90063-f [doi]
PST - ppublish
SO  - Hum Immunol. 1991 Jan;30(1):7-10. doi: 10.1016/0198-8859(91)90063-f.