PMID- 20019905
OWN - NLM
STAT- MEDLINE
DCOM- 20100303
LR  - 20220408
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 117
IP  - 10
DP  - 2009 Oct
TI  - Perinatal exposure to bisphenol a alters early adipogenesis in the rat.
PG  - 1549-55
LID - 10.1289/ehp.11342 [doi]
AB  - BACKGROUND: The causes of the current obesity pandemic have not been fully 
      elucidated. Implication of environmental endocrine disruptors such as bisphenol A 
      (BPA) on adipose tissue development has been poorly investigated. OBJECTIVES: The 
      aim of the present study was to evaluate the effects of perinatal exposure to BPA 
      on early adipose storage at weaning. METHODS: Pregnant Sprague-Dawley rats had 
      access to drinking water containing 1 mg/L BPA from day 6 of gestation through 
      the end of lactation. Pups were weaned on postnatal day (PND) 21. At that time, 
      we investigated perigonadal adipose tissue of pups (weight, histology, gene 
      expression). For the remaining animals, we recorded body weight and food intake 
      for animals on either standard chow or a high-fat diet. RESULTS: Gestational 
      exposure to BPA did not alter the sex ratio or litter size at birth. On PND1, the 
      weight of male and female BPA-exposed pups was increased. On PND21, body weight 
      was increased only in females, in which parametrial white adipose tissue (pWAT) 
      weight was increased about 3-fold. This excess of pWAT was associated with 
      adipocyte hypertrophy and overexpression of lipogenic genes such as C/EBP-alpha 
      (CAAT enhancer binding protein alpha), PPAR-gamma (peroxisome 
      proliferator-activated receptor gamma), SREBP-1C (sterol regulatory element 
      binding protein-1C), LPL (lipoprotein lipase), FAS (fatty acid synthase), and 
      SCD-1 (stearoyl-CoA desaturase 1). In addition, gene expression of SREBP-1C, FAS, 
      and ACC (acetyl-CoA carboxylase) was also increased in liver from BPA-exposed 
      females at PND21, without a change in circulating lipids and glucose. After 
      weaning, perinatal BPA exposure predisposed to overweight in a sex- and 
      diet-dependent manner. We observed no change in food intake due to perinatal BPA 
      exposure in rats on either standard chow or a high-fat diet. CONCLUSIONS: 
      Perinatal exposure to a low dose of BPA increased adipogenesis in females at 
      weaning. Adult body weight may be programmed during early life, leading to 
      changes dependent on the sex and the nutritional status. Although further studies 
      are required to understand the mechanisms of BPA action in early life, these 
      results are particularly important with regard to the increasing prevalence of 
      childhood obesity and the context-dependent action of endocrine disruptors.
FAU - Somm, Emmanuel
AU  - Somm E
AD  - Faculty of Medicine, University of Geneva, Geneva, Switzerland. 
      emmanuel.somm@medecine.unige.ch
FAU - Schwitzgebel, Valerie M
AU  - Schwitzgebel VM
FAU - Toulotte, Audrey
AU  - Toulotte A
FAU - Cederroth, Christopher R
AU  - Cederroth CR
FAU - Combescure, Christophe
AU  - Combescure C
FAU - Nef, Serge
AU  - Nef S
FAU - Aubert, Michel L
AU  - Aubert ML
FAU - Huppi, Petra S
AU  - Huppi PS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090629
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (CCAAT-Enhancer-Binding Protein-alpha)
RN  - 0 (Environmental Pollutants)
RN  - 0 (PPAR gamma)
RN  - 0 (Phenols)
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Adipogenesis/*drug effects
MH  - Adipose Tissue/*drug effects/embryology/metabolism
MH  - Animals
MH  - Benzhydryl Compounds
MH  - Body Weight/drug effects
MH  - CCAAT-Enhancer-Binding Protein-alpha/genetics
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Gene Expression Regulation, Developmental/*drug effects/genetics
MH  - In Vitro Techniques
MH  - Lipogenesis/drug effects
MH  - Litter Size/drug effects
MH  - Liver/metabolism
MH  - Male
MH  - PPAR gamma/genetics
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sex Ratio
MH  - Sterol Regulatory Element Binding Protein 1/genetics
MH  - Weaning
PMC - PMC2790509
OTO - NOTNLM
OT  - adipocyte
OT  - adipose tissue
OT  - bisphenol A
OT  - food intake
OT  - obesity
EDAT- 2009/12/19 06:00
MHDA- 2010/03/04 06:00
PMCR- 2009/10/01
CRDT- 2009/12/19 06:00
PHST- 2008/02/07 00:00 [received]
PHST- 2009/06/29 00:00 [accepted]
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/03/04 06:00 [medline]
PHST- 2009/10/01 00:00 [pmc-release]
AID - ehp-117-1549 [pii]
AID - 10.1289/ehp.11342 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2009 Oct;117(10):1549-55. doi: 10.1289/ehp.11342. Epub 
      2009 Jun 29.