PMID- 20020850
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20091221
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 18
IP  - 8
DP  - 2008 Jan
TI  - Epigallocatechin gallate, a green tea phytochemical, attenuates alcohol-induced 
      hepatic protein and lipid damage.
PG  - 645-52
LID - 10.1080/15376510701884985 [doi]
AB  - ABSTRACT Oxidative damage to cellular constituents is one of the major mechanisms 
      of alcoholic liver injury, and administration of antioxidants ameliorates 
      alcoholic liver disease. The present study investigated the influence of (-) 
      epigallocatechin gallate (EGCG), a major polyphenol component of green tea, on 
      oxidant-antioxidant balance, protein, and lipid damage in liver of rats fed 
      ethanol. Chronic ethanol administration (6 g/kg/day x 60 days) caused liver 
      damage that was manifested by excessive formation of lipid peroxidation end 
      products such as thiobarbituric acid-reactive substances (TBARS), lipid 
      hydroperoxides (LHP), and conjugated dienes (CD) accompanied by a reduction in 
      enzymic and non-enzymic antioxidant levels. Further, ethanol caused a rise in 
      protein carbonyl formation and loss of protein thiol groups. Ethanol-fed rats 
      exhibited increased staining for the presence of 4-hydroxynonenal (4-HNE), 
      3-nitrotyrosine (3-NT), and 2,4-dinitrophenol (DNP) protein adducts in liver. The 
      detrimental effects of ethanol were alleviated upon simultaneous treatment with 
      EGCG (100 mg/kg/day) for the last 30 days of alcohol feeding. These findings show 
      that EGCG ameliorates protein and lipid damage induced by the hepatotoxin, 
      ethanol.
FAU - Kaviarasan, S
AU  - Kaviarasan S
AD  - Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai 
      University, Annamalai Nagar, India.
FAU - Sundarapandiyan, R
AU  - Sundarapandiyan R
FAU - Anuradha, C V
AU  - Anuradha CV
LA  - eng
PT  - Journal Article
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
EDAT- 2008/01/01 00:00
MHDA- 2008/01/01 00:01
CRDT- 2009/12/22 06:00
PHST- 2009/12/22 06:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2008/01/01 00:01 [medline]
AID - 10.1080/15376510701884985 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2008 Jan;18(8):645-52. doi: 10.1080/15376510701884985.