PMID- 20020855
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20091221
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 18
IP  - 7
DP  - 2008 Jan
TI  - The effects of inhaled formaldehyde on oxidant and antioxidant systems of rat 
      cerebellum during the postnatal development process.
PG  - 569-74
LID - 10.1080/15376510701555288 [doi]
AB  - ABSTRACT The aim of this study was to examine the effects of formaldehyde (FA) 
      inhalation during the early postnatal period on some oxidant and antioxidant 
      systems of rat cerebellum in the developmental process and to determine whether 
      the changes were reversible or not. After birth, 0 (control), 6, or 12 ppm FA5 
      was given to the neonatal rats throughout 30 days. This was done by placing them 
      for 6 h/day and 5 day/week in a glass chamber containing FA vapor. After 
      cessation of the FA exposing process, seven rats from each group were decapitated 
      on postnatal day (PND) 30 and the remaining seven rats were decapitated on the 
      PND 90, and all cerebellums were removed immediately. On samples, levels of 
      malondialdehyde (MDA) and nitric oxide (NO) and activities of total superoxide 
      dismutase (t-SOD) and glutathione peroxidase (GSH-px) enzymes were measured. We 
      found that activity of GSH-Px and levels of MDA and NO increased; on the other 
      hand, activity of t-SOD decreased significantly in the rats treated with FA 
      compared to control rats at PND 30. In general, the findings at PND 90 were 
      similar to PND 30. Additionally, we observed that the 12-ppm FA-inhaling rats 
      were more affected than the 6-ppm FA-inhaling rats, especially at PND 30. As a 
      result, the present findings suggest that inhalation of FA during the early 
      postnatal period affects the oxidant and antioxidant systems and increases some 
      free radicals in the rat cerebellum in a dose-related manner. We think that these 
      changes were carried on for a long time or may cause irreversible toxicity and 
      oxidative damage.
FAU - Songur, Ahmet
AU  - Songur A
AD  - Kocatepe University, School of Medicine, Department of Anatomy, Afyonkarahisar, 
      Turkey.
FAU - Sarsilmaz, Mustafa
AU  - Sarsilmaz M
FAU - Ozen, Oguz
AU  - Ozen O
FAU - Sahin, Semsettin
AU  - Sahin S
FAU - Koken, Resit
AU  - Koken R
FAU - Zararsiz, Ismail
AU  - Zararsiz I
FAU - Ilhan, Necip
AU  - Ilhan N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
EDAT- 2008/01/01 00:00
MHDA- 2008/01/01 00:01
CRDT- 2009/12/22 06:00
PHST- 2009/12/22 06:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2008/01/01 00:01 [medline]
AID - 10.1080/15376510701555288 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2008 Jan;18(7):569-74. doi: 10.1080/15376510701555288.