PMID- 20021397
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20191111
IS  - 1874-6128 (Electronic)
IS  - 1874-6098 (Linking)
VI  - 2
IP  - 1
DP  - 2009 Mar
TI  - The association of very high hair manganese accumulation and high oxidative 
      stress in Mongolian people.
PG  - 28-42
AB  - Oxidative stress induces several diseases and early aging. Previously, we 
      reported that Mongolians are exposed in high oxidative stress, which may cause 
      their early aging. In this study, to know the reason of high oxidative stress, we 
      measured hair metals. This investigation was performed in Murun city, in the 
      northern area of this country, and 469 healthy subjects, ranging from 10 to 82 
      years of age, were randomly enrolled. Oxidative stress was evaluated by the 
      levels of serum reactive oxygen metabolites (ROM), malondialdehyde-modified 
      low-density lipoprotein (MDA-LDL) and urinary 8-hydroxy-2'-deoxyguanosine 
      (8-OHdG). Antioxidant capacity (AOC) was estimated by the levels of biological 
      antioxidant potential (BAP) and superoxide dismutase (SOD) activity. Scalp hair 
      metals were measured using an inductively coupled plasma mass spectrometry 
      method. Murun subjects showed high ROM levels of 394+/-75 Carr U (n=342), 
      compared with Japanese healthy subjects (n=356, 326+/-51 Carr U, p<0.001). 
      MDA-LDL and 8-OHdG levels also showed high levels. While, BAP levels of Murun 
      subjects were 2263+/-203 micromol/L (n=210), Japanese subjects (n=356, 2087+/-215 
      micromol/L, p<0.001). SOD activities were also high, suggesting that the high 
      oxidative may accelerate the state of AOC. Murun subjects demonstrated high 
      accumulation of several metals in the hairs. In particular, Mn accumulation 
      exhibited from 2 fold to 40 fold increases of Japanese standard. These findings 
      are indicative that the high Mn accumulation may contribute to the high oxidative 
      stress. The mechanism of its high accumulation was not explained by food 
      materials or drinking water. We should further investigate another influence such 
      as sandy wind. In order to suppress the high oxidative stress, elimination of the 
      high Mn accumulation should be urgently studied.
FAU - Komatsu, Fumio
AU  - Komatsu F
AD  - Kagawa Nutrition University, 3-9-21, Chiyoda, Sakado, Saitama, 350-0288, Japan. 
      komatsu@eiyo.ac.jp
FAU - Kagawa, Yasuo
AU  - Kagawa Y
FAU - Ishiguro, Kiyomi
AU  - Ishiguro K
FAU - Kawabata, Terue
AU  - Kawabata T
FAU - Purvee, Baatar
AU  - Purvee B
FAU - Otgon, Jugder
AU  - Otgon J
FAU - Chimedregzen, Ulziiburen
AU  - Chimedregzen U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Aging Sci
JT  - Current aging science
JID - 101473576
RN  - 0 (Biomarkers)
RN  - 0 (Soil)
RN  - 059QF0KO0R (Water)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*ethnology/*metabolism
MH  - Biomarkers/metabolism
MH  - Child
MH  - Female
MH  - Food Analysis
MH  - Hair/*metabolism
MH  - Humans
MH  - Japan
MH  - Male
MH  - Manganese/analysis/*metabolism
MH  - Middle Aged
MH  - Mongolia
MH  - Oxidative Stress/*physiology
MH  - Soil/analysis
MH  - Water/analysis
MH  - Young Adult
EDAT- 2009/12/22 06:00
MHDA- 2010/03/12 06:00
CRDT- 2009/12/22 06:00
PHST- 2009/12/22 06:00 [entrez]
PHST- 2009/12/22 06:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
AID - 10.2174/1874609810902010028 [doi]
PST - ppublish
SO  - Curr Aging Sci. 2009 Mar;2(1):28-42. doi: 10.2174/1874609810902010028.