PMID- 20021487
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20131121
IS  - 1741-4520 (Electronic)
IS  - 0914-3505 (Linking)
VI  - 49
IP  - 4
DP  - 2009 Dec
TI  - Early embryonic losses in mice induced by diethylstilbestrol.
PG  - 269-73
LID - 10.1111/j.1741-4520.2009.00247.x [doi]
AB  - Estrogens cause embryonic lethality and the disturbance of early placental 
      development in mice. Diethylstilbestrol (DES) at 1, 10, or 100 microg/kg was 
      orally administered to Institute of Cancer Research mice on gestational days (GD) 
      4 through 8, and the uterus and placenta were examined histopathologically on GD 
      9. Decidua of DES-treated mice showed insufficient development, and the uterine 
      lumen at the implantation site did not effectively minimize. The trophoblast 
      giant cell layer was not separated from the uterine lumen by the decidua 
      capsularis, and hemorrhage from the denuded trophoblast giant cell layer into the 
      uterine lumen was noted at the peripheral part of the decidua basalis. The 
      results of the present study suggest that decidual hypoplasia and subsequent 
      placental hemorrhage causes fetal death due to the administration of DES during 
      the early stage of pregnancy.
FAU - Nagao, Tetsuji
AU  - Nagao T
AD  - Department of Life Science, Kinki University, Higashi-Osaka, Japan. 
      tnagao@life.kindai.ac.jp
FAU - Yoshimura, Shinsuke
AU  - Yoshimura S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Congenit Anom (Kyoto)
JT  - Congenital anomalies
JID - 9306292
RN  - 731DCA35BT (Diethylstilbestrol)
SB  - IM
MH  - Animals
MH  - Decidua/drug effects
MH  - Diethylstilbestrol/pharmacology/*toxicity
MH  - Embryo Loss/*chemically induced
MH  - Embryo, Mammalian/drug effects
MH  - Female
MH  - Gestational Age
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Pregnancy
MH  - Trophoblasts/drug effects
EDAT- 2009/12/22 06:00
MHDA- 2010/03/05 06:00
CRDT- 2009/12/22 06:00
PHST- 2009/12/22 06:00 [entrez]
PHST- 2009/12/22 06:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
AID - CGA247 [pii]
AID - 10.1111/j.1741-4520.2009.00247.x [doi]
PST - ppublish
SO  - Congenit Anom (Kyoto). 2009 Dec;49(4):269-73. doi: 
      10.1111/j.1741-4520.2009.00247.x.