PMID- 20021924
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20111017
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 37
IP  - 8
DP  - 2009 Aug
TI  - [Prognostic value of point of care B-type natriuretic peptide testing and GRACE 
      score in patients with acute coronary syndrome].
PG  - 716-20
AB  - OBJECTIVE: To compare the prognostic value of B-type natriuretic peptide (BNP) 
      and GRACE score in patients with acute coronary syndrome. METHODS: A total of 246 
      patients with chest pain to hospital time < 24 hours were followed up to 30 days. 
      Admission plasma B-type natriuretic peptide was measured by point-of-care. 
      Endpoints included death, reinfarction, recurrent ischemia and new onset of 
      congestive heart failure. The receiver operating characteristic (ROC) curve was 
      used to evaluate prognostic value of BNP and GRACE score. The logistic regression 
      models were used to assess the prognostic contribution of BNP level and GRACE 
      score. RESULTS: The mean age was (67.6 +/- 12.0) years (61.8% males) and ST 
      elevation myocardial infarction (STEMI) was diagnosed in 135 patients (54.9%). 
      During the follow up, 34 endpoints (13.8%) were recorded including 9 deaths 
      (3.7%). The systolic blood pressure [(121 +/- 29) mm Hg vs. (130 +/- 23) mm Hg, P 
      = 0.034; 1 mm Hg = 0.133 kPa] was significantly lower while the heart rate and 
      plasma creatinine were significantly higher in the endpoints group than in 
      non-endpoints group. TNI and CRP levels were similar between the two groups. The 
      BNP level at admission (median 883.5 ng/L vs. 216.5 ng/L) and GRACE score (median 
      164.5 vs. 142.0) were significantly higher in the endpoints group than in 
      non-endpoints group (all P < 0.05). The prognostic criteria for BNP level (area 
      under cure, 0.704) was 194.5 ng/L determined by ROC (P = 0.043). For GRACE score, 
      the predictive value for endpoints was 0.742 (P = 0.003) and the cut-off point 
      was 158. In the logistic regression model, BNP concentration (> 194.5 ng/L, OR = 
      3.174) and GRACE score (> 158, OR = 4.031) were independent predictors of 
      endpoints in patients with ACS. CONCLUSION: Both BNP level at admission and GRACE 
      score were independent predictors for endpoints at 30 days in patients with ACS.
FAU - Sun, Yi-hong
AU  - Sun YH
AD  - Department of Cardiology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Wang, Gui-lian
AU  - Wang GL
FAU - Fu, Yuan-yuan
AU  - Fu YY
FAU - Xue, Chao
AU  - Xue C
FAU - Hu, Da-yi
AU  - Hu DY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Acute Coronary Syndrome/*diagnosis
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*analysis
MH  - Prognosis
MH  - ROC Curve
MH  - Risk Assessment
EDAT- 2009/12/22 06:00
MHDA- 2010/05/12 06:00
CRDT- 2009/12/22 06:00
PHST- 2009/12/22 06:00 [entrez]
PHST- 2009/12/22 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Aug;37(8):716-20.