PMID- 20026184
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20141120
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 469
IP  - 3
DP  - 2010 Jan 29
TI  - MDMA ("ecstasy") impairs learning in the Morris Water Maze and reduces 
      hippocampal LTP in young rats.
PG  - 375-9
LID - 10.1016/j.neulet.2009.12.031 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA), an important recreational 
      psychostimulant drug, was examined for its ability to alter visuo-spatial 
      learning and synaptic plasticity. Young rats received MDMA (0.2 and 2mg/kg s.c.) 
      twice per day for 6 days while their visuo-spatial learning was tested using the 
      Morris Water Maze. After this, animals were sacrificed and LTP induced in 
      hippocampal slices. Visuo-spatial learning was impaired and LTP reduced, both 
      dose-dependently, without changes in serotonin levels or paired-pulse 
      facilitation. We conclude that low, nontoxic doses of MDMA, applied during 
      several days, slow learning by impairing postsynaptic plasticity.
CI  - (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Arias-Cavieres, Alejandra
AU  - Arias-Cavieres A
AD  - Department of Biology, Faculty of Chemistry and Biology, University of Santiago 
      de Chile, Chile.
FAU - Rozas, Carlos
AU  - Rozas C
FAU - Reyes-Parada, Miguel
AU  - Reyes-Parada M
FAU - Barrera, Nelson
AU  - Barrera N
FAU - Pancetti, Floria
AU  - Pancetti F
FAU - Loyola, Sebastian
AU  - Loyola S
FAU - Lorca, Ramon A
AU  - Lorca RA
FAU - Zeise, Marc L
AU  - Zeise ML
FAU - Morales, Bernardo
AU  - Morales B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091218
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Central Nervous System Stimulants)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Aging
MH  - Animals
MH  - CA1 Region, Hippocampal/*drug effects/physiology
MH  - Central Nervous System Stimulants/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Maze Learning/*drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Neuronal Plasticity/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Space Perception/drug effects/physiology
MH  - Swimming
MH  - Time Factors
MH  - Visual Perception/drug effects/physiology
EDAT- 2009/12/23 06:00
MHDA- 2010/04/13 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/11/06 00:00 [received]
PHST- 2009/12/09 00:00 [revised]
PHST- 2009/12/12 00:00 [accepted]
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
AID - S0304-3940(09)01601-2 [pii]
AID - 10.1016/j.neulet.2009.12.031 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Jan 29;469(3):375-9. doi: 10.1016/j.neulet.2009.12.031. Epub 
      2009 Dec 18.