PMID- 20026310
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20211020
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1317
DP  - 2010 Mar 4
TI  - Selective enhancement of main olfactory input to the medial amygdala by GnRH.
PG  - 46-59
LID - 10.1016/j.brainres.2009.10.078 [doi]
AB  - In male hamsters mating behavior is dependent on chemosensory input from the main 
      olfactory and vomeronasal systems, whose central pathways contain cell bodies and 
      fibers of gonadotropin-releasing hormone (GnRH) neurons. In sexually naive males, 
      vomeronasal organ removal (VNX), but not main olfactory lesions, impairs mating 
      behavior. Intracerebroventricular (i.c.v.)-GnRH restores mating in sexually naive 
      VNX males and enhances medial amygdala (Me) immediate-early gene activation by 
      chemosensory stimulation. In sexually experienced males, VNX does not impair 
      mating and i.c.v.-GnRH suppresses Me activation. Thus, the main olfactory system 
      is sufficient for mating in experienced-VNX males, but not in naive-VNX males. We 
      investigated the possibility that GnRH enhances main olfactory input to the 
      amygdala in naive-VNX males using i.c.v.-GnRH and pharmacological stimulation 
      (bicuculline/D,L-homocysteic acid mixture) of the main olfactory bulb (MOB). In 
      sexually naive intact males there was a robust increase of Fos protein expression 
      in the anteroventral medial amygdala (MeAv) with MOB stimulation, but no effect 
      of GnRH. There was no effect of stimulation or GnRH in posterodorsal medial 
      amygdala (MePd). In naive-VNX animals, GnRH increased Fos in MeAv and MePv. Only 
      combined MOB stimulation and i.c.v.-GnRH produced a significant increase in Fos 
      in the dorsal (reproduction-related) portion of MeP (MePd). When the animals were 
      sexually experienced before VNX, a condition in which GnRH does not enhance 
      mating, i.c.v.-GnRH combined with MOB stimulation suppressed Fos expression in 
      MePd. This suggests a more selective effect of GnRH on olfactory input in MePd 
      than elsewhere in medial amygdala of VNX males.
CI  - 2009 Elsevier B.V. All rights reserved.
FAU - Blake, Camille Bond
AU  - Blake CB
AD  - Department of Biological Science, Program in Neuroscience, 3012 King Life Science 
      Building, 319 Stadium Drive, Florida State University, Tallahassee, FL 
      32306-4295, USA. Camille.blake@uky.edu
FAU - Meredith, Michael
AU  - Meredith M
LA  - eng
GR  - F31 DC07782/DC/NIDCD NIH HHS/United States
GR  - F31 DC007782-01/DC/NIDCD NIH HHS/United States
GR  - DC 005813/DC/NIDCD NIH HHS/United States
GR  - T32 DC000044/DC/NIDCD NIH HHS/United States
GR  - T32 DC00044/DC/NIDCD NIH HHS/United States
GR  - F31 DC007782/DC/NIDCD NIH HHS/United States
GR  - R01 DC005813/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091222
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Central Nervous System Agents)
RN  - 0 (GABA Antagonists)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 1001-13-4 (homocysteic acid)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Bicuculline/pharmacology
MH  - Central Nervous System Agents/pharmacology
MH  - Cerebral Cortex/physiology
MH  - Cricetinae
MH  - GABA Antagonists/pharmacology
MH  - Genes, Immediate-Early
MH  - Gonadotropin-Releasing Hormone/*metabolism
MH  - Homocysteine/analogs & derivatives/pharmacology
MH  - Male
MH  - Mesocricetus
MH  - Models, Neurological
MH  - Olfactory Bulb/drug effects/physiology
MH  - Olfactory Pathways/drug effects/injuries/*physiology
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - Vomeronasal Organ/injuries/physiology
PMC - PMC2821963
MID - NIHMS167534
EDAT- 2009/12/23 06:00
MHDA- 2010/05/21 06:00
PMCR- 2011/03/04
CRDT- 2009/12/23 06:00
PHST- 2008/10/27 00:00 [received]
PHST- 2009/10/11 00:00 [revised]
PHST- 2009/10/12 00:00 [accepted]
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
PHST- 2011/03/04 00:00 [pmc-release]
AID - S0006-8993(09)02663-8 [pii]
AID - 10.1016/j.brainres.2009.10.078 [doi]
PST - ppublish
SO  - Brain Res. 2010 Mar 4;1317:46-59. doi: 10.1016/j.brainres.2009.10.078. Epub 2009 
      Dec 22.