PMID- 20026563
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20211020
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 49
IP  - 3
DP  - 2010 Mar
TI  - Towards understanding the phenotypes of myocardial involvement in the presence of 
      self-limiting and sustained systemic inflammation: a magnetic resonance imaging 
      study.
PG  - 528-35
LID - 10.1093/rheumatology/kep426 [doi]
AB  - OBJECTIVE: To investigate the patterns of myocardial involvement in the presence 
      of self-limiting and sustained systemic inflammation, using MRI. METHODS: 
      Ninety-four subjects, with a clinical diagnosis of myocarditis (n = 36), RA (n = 
      24) and apparently healthy subjects (n = 34, control group), underwent 
      standardized cardiac MRI protocol for the assessment of global and regional 
      morphology and systolic function using balanced steady-state free precession 
      sequences, T2-weighted images and late gadolinium enhancement (LGE) studies. 
      RESULTS: The three groups were well matched for age, gender and cardiovascular 
      risk factors. The RA group showed markedly increased end-diastolic volumes and 
      reduced ejection fraction (P < 0.05). Antero/inferolateral wall thickness was 
      greater in the myocarditis group and reduced in RA, associated with reduced 
      radial and longitudinal thickening (P < 0.01), and markedly raised T2-oedema 
      ratio and global LGE scores (P < 0.05). CONCLUSIONS: Our results may signify the 
      phenotypic features of myocardial plasticity and deformation in response to 
      self-limiting and sustained inflammatory injury.
FAU - Puntmann, Valentina O
AU  - Puntmann VO
AD  - Department of Experimental Medicine, Imperial College London, London W12 0NN, UK. 
      v.puntmann@imperial.ac.uk
FAU - Taylor, Peter C
AU  - Taylor PC
FAU - Barr, Andrew
AU  - Barr A
FAU - Schnackenburg, Bernhard
AU  - Schnackenburg B
FAU - Jahnke, Cosima
AU  - Jahnke C
FAU - Paetsch, Ingo
AU  - Paetsch I
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20091221
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/pathology/*physiopathology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/pathology/*physiopathology
MH  - Phenotype
MH  - Stroke Volume/physiology
MH  - Ventricular Function, Left/physiology
MH  - Ventricular Remodeling/physiology
PMC - PMC2820266
EDAT- 2009/12/23 06:00
MHDA- 2010/12/14 06:00
PMCR- 2009/12/21
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2009/12/21 00:00 [pmc-release]
AID - kep426 [pii]
AID - 10.1093/rheumatology/kep426 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2010 Mar;49(3):528-35. doi: 10.1093/rheumatology/kep426. 
      Epub 2009 Dec 21.