PMID- 20027173
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20151119
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 30 Suppl 1
DP  - 2009
TI  - Fish biochemical markers as a tool for pollution assessment on the Svitava and 
      Svratka rivers, Czech Republic.
PG  - 211-8
AB  - OBJECTIVES: The study was designed to assess the pollution of the Svitava and 
      Svratka rivers in and around the industrial city of Brno (Czech Republic) by 
      persistent organic pollutants using selected biochemical markers in chub. DESIGN: 
      Levels of selected biochemical markers were measured in liver and plasma samples 
      of chub. The concentrations of persistent organic pollutants (POPs) were 
      determined in bottom sediment, semi-permeable membrane devices (SPMDs) and muscle 
      samples, and consequently used for correlation with biochemical markers. RESULTS: 
      Significant alterations (p < 0.05) in some biochemical markers were observed and 
      associated with combined exposure to pollutants. The highest levels of pollutants 
      were found at sites situated downstream from Brno. The most widespread changes 
      were identified in the function of phase I detoxifying enzymes. Significant 
      positive correlations were observed in cytochrome P450 content and DDT 
      concentration in the semi-permeable membrane device (p = 0.019, rs = 0.886), and 
      between ethoxyresorufin-O-deethylase activity and content of DDT (p = 0.041, rs = 
      0.352) and polychlorinated biphenyls (p = 0.034, rs = 0.365) in muscle tissues of 
      indicator fish. CONCLUSION: The results presented in our study indicate the 
      highest contamination of sites situated downstream from Brno, where the intensive 
      industrial and agricultural activities as well as domestic waste and sewage most 
      probably comprise the main impact sources of the enhanced level of pollutants and 
      some biochemical markers in fish.
FAU - Blahova, Jana
AU  - Blahova J
AD  - Department of Veterinary Public Health and Toxicology, University of Veterinary 
      and Pharmaceutical Sciences Brno, Czech Republic. blahovaj@vfu.cz
FAU - Havelkova, Marcela
AU  - Havelkova M
FAU - Kruzikova, Kamila
AU  - Kruzikova K
FAU - Kovarova, Jana
AU  - Kovarova J
FAU - Harustiakova, Danka
AU  - Harustiakova D
FAU - Kasikova, Barbora
AU  - Kasikova B
FAU - Hypr, Dusan
AU  - Hypr D
FAU - Jurcikova, Jana
AU  - Jurcikova J
FAU - Ocelka, Tomas
AU  - Ocelka T
FAU - Svobodova, Zdenka
AU  - Svobodova Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (Biomarkers)
RN  - 0 (Water Pollutants)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Animals
MH  - Biomarkers/analysis/blood/metabolism
MH  - Cyprinidae/*metabolism
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Cytochrome P-450 Enzyme System/metabolism
MH  - Czech Republic
MH  - DDT/analysis/metabolism
MH  - Environmental Exposure
MH  - Liver/chemistry/enzymology/metabolism
MH  - Male
MH  - Muscle, Skeletal/chemistry/enzymology/metabolism
MH  - Polychlorinated Biphenyls/analysis/metabolism
MH  - Rivers/*chemistry
MH  - Water Pollutants/*analysis/metabolism
MH  - Water Pollution/*analysis
EDAT- 2009/12/23 06:00
MHDA- 2010/05/25 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/07/16 00:00 [received]
PHST- 2009/09/25 00:00 [accepted]
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - NEL300709A36 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2009;30 Suppl 1:211-8.