PMID- 20030786
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 75
IP  - 3
DP  - 2010 Mar
TI  - HLA-G*0105N and HLA-G 14 bp dimorphisms in exon 8 in four distinct populations in 
      mainland China.
PG  - 227-34
LID - 10.1111/j.1399-0039.2009.01427.x [doi]
AB  - In this study, we investigated human leukocyte antigen (HLA)-G*0105N and the 14 
      bp deletion/insertion polymorphism in exon 8 of the HLA-G gene in 600 individuals 
      from two southern Chinese Han populations (Hunan Han and Guangdong Han) and two 
      northern Chinese populations (Inner Mongolia Han and Inner Mongolia Mongol), we 
      also studied the linkage disequilibrium (LD) between HLA-G and HLA-A locus in 
      these four populations. Our data showed that (1) the allele and haplotype 
      frequencies of HLA-G and HLA-A loci did not differ significantly between the two 
      southern Chinese Han populations, and showed remarkable homogeneity in the two 
      northern Chinese populations; (2) HLA-G*0105N had significantly higher 
      frequencies in the two northern Chinese populations with a frequency of 10.1% in 
      the Inner Mongolia Han population, HLA-G 14 bp deletion/insertion frequency did 
      not differ significantly between the southern and northern Chinese populations; 
      (3) Ewens-Watterson homozygosity statistics at HLA-G*0105N, HLA-G 14 bp 
      deletion/insertion polymorphism and HLA-A were consistent with neutral 
      expectations for all populations; (4) HLA-G*0105N allele harbored the HLA-G 14 bp 
      insertion in exon 8 and was linked to HLA-A*30, five HLA-G*0105N homozygotes were 
      detected in the four populations; (5) haplotypes HLA-A*30-HLA-G*0105N and 
      HLA-A*02-HLA-G 14 bp deletion were in significant LD across four populations, 
      other LD patterns were more population-specific. Our data suggest that 
      HLA-A*30-HLA-G*0105N-HLA-G 14 bp insertion is a conserved haplotype, the ethnic 
      and/or geographic difference in HLA-G*0105N and HLA-G 14 bp distribution could 
      largely be attributable to demographic factors other than selection. The LD 
      patterns uncovered will facilitate the understanding of HLA-G role in 
      associations previously described between HLA-A subregion and diseases.
FAU - Tian, W
AU  - Tian W
AD  - Immunogenetics Research Group, Department of Immunology, College of Basic Medical 
      Sciences, Central South University, Changsha, Hunan, China. tianwei3@yahoo.com
FAU - Cai, J H
AU  - Cai JH
FAU - Wang, F
AU  - Wang F
FAU - Li, L X
AU  - Li LX
FAU - Cao, Y
AU  - Cao Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091218
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Blood Group Antigens)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - Blood Group Antigens/genetics
MH  - China
MH  - *Exons
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-G Antigens
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Mutagenesis, Insertional
MH  - *Polymorphism, Genetic
MH  - Population/*genetics
MH  - Sequence Deletion
EDAT- 2009/12/25 06:00
MHDA- 2010/06/19 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - TAN1427 [pii]
AID - 10.1111/j.1399-0039.2009.01427.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Mar;75(3):227-34. doi: 10.1111/j.1399-0039.2009.01427.x. 
      Epub 2009 Dec 18.