PMID- 20032191
OWN - NLM
STAT- MEDLINE
DCOM- 20100317
LR  - 20221207
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 84
IP  - 5
DP  - 2010 Mar
TI  - Human leukocyte antigen class I supertypes and HIV-1 control in African 
      Americans.
PG  - 2610-7
LID - 10.1128/JVI.01962-09 [doi]
AB  - The role of human leukocyte antigen (HLA) class I supertypes in controlling human 
      immunodeficiency virus type 1 (HIV-1) infection in African Americans has not been 
      established. We examined the effects of the HLA-A and HLA-B alleles and 
      supertypes on the outcomes of HIV-1 clade B infection among 338 African American 
      women and adolescents. HLA-B58 and -B62 supertypes (B58s and B62s) were 
      associated with favorable HIV-1 disease control (proportional odds ratio [POR] of 
      0.33 and 95% confidence interval [95% CI] of 0.21 to 0.52 for the former and POR 
      of 0.26 and 95% CI of 0.09 to 0.73 for the latter); B7s and B44s were associated 
      with unfavorable disease control (POR of 2.39 and 95% CI of 1.54 to 3.73 for the 
      former and POR of 1.63 and 95% CI of 1.08 to 2.47 for the latter). In general, 
      individual alleles within specific B supertypes exerted relatively homogeneous 
      effects. A notable exception was B27s, whose protective influence (POR, 0.58; 95% 
      CI, 0.35 to 0.94) was masked by the opposing effect of its member allele B*1510. 
      The associations of most B supertypes (e.g., B58s and B7s) were largely explained 
      either by well-known effects of constituent B alleles or by effects of previously 
      unimplicated B alleles aggregated into a particular supertype (e.g., B44s and 
      B62s). A higher frequency of HLA-B genotypic supertypes correlated with a higher 
      mean viral load (VL) and lower mean CD4 count (Pearson's r = 0.63 and 0.62, 
      respectively; P = 0.03). Among the genotypic supertypes, B58s and its member 
      allele B*57 contributed disproportionately to the explainable VL variation. The 
      study demonstrated the dominant role of HLA-B supertypes in HIV-1 clade 
      B-infected African Americans and further dissected the contributions of 
      individual class I alleles and their population frequencies to the supertype 
      effects.
FAU - Lazaryan, Aleksandr
AU  - Lazaryan A
AD  - University of Alabama at Birmingham, Birmingham, Alabama 35294-0022, USA.
FAU - Song, Wei
AU  - Song W
FAU - Lobashevsky, Elena
AU  - Lobashevsky E
FAU - Tang, Jianming
AU  - Tang J
FAU - Shrestha, Sadeep
AU  - Shrestha S
FAU - Zhang, Kui
AU  - Zhang K
FAU - Gardner, Lytt I
AU  - Gardner LI
FAU - McNicholl, Janet M
AU  - McNicholl JM
FAU - Wilson, Craig M
AU  - Wilson CM
FAU - Klein, Robert S
AU  - Klein RS
FAU - Rompalo, Anne
AU  - Rompalo A
FAU - Mayer, Kenneth
AU  - Mayer K
FAU - Sobel, Jack
AU  - Sobel J
FAU - Kaslow, Richard A
AU  - Kaslow RA
CN  - HIV Epidemiology Research Study
CN  - Reaching for Excellence in Adolescent Care and Health Study
LA  - eng
GR  - R01 AI071906/AI/NIAID NIH HHS/United States
GR  - U01 HD040533/HD/NICHD NIH HHS/United States
GR  - U01 HD32830/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20091223
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Black or African American/*genetics
MH  - Alleles
MH  - Child
MH  - Female
MH  - Genotype
MH  - HIV Infections/*ethnology/genetics/*immunology/*prevention & control
MH  - HIV-1/*immunology
MH  - HLA-A Antigens/genetics/immunology
MH  - HLA-B Antigens/genetics/immunology
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Middle Aged
MH  - Odds Ratio
MH  - Viral Load
MH  - Young Adult
PMC - PMC2820922
FIR - Klein, Robert S
IR  - Klein RS
FIR - Schoenbaum, Ellie
IR  - Schoenbaum E
FIR - Arnsten, Julia
IR  - Arnsten J
FIR - Burk, Robert D
IR  - Burk RD
FIR - Demas, Penelope
IR  - Demas P
FIR - Howard, Andrea
IR  - Howard A
FIR - Schuman, Paula
IR  - Schuman P
FIR - Sobel, Jack
IR  - Sobel J
FIR - Lancaster, Wayne
IR  - Lancaster W
FIR - Rompalo, Anne
IR  - Rompalo A
FIR - Vlahov, David
IR  - Vlahov D
FIR - Celentano, David
IR  - Celentano D
FIR - Carpenter, Charles
IR  - Carpenter C
FIR - Mayer, Kenneth
IR  - Mayer K
FIR - Cu-Uvin, Susan
IR  - Cu-Uvin S
FIR - Flanigan, Timothy
IR  - Flanigan T
FIR - Hogan, Joseph
IR  - Hogan J
FIR - Rich, Josiah
IR  - Rich J
FIR - Gardner, Lytt I
IR  - Gardner LI
FIR - Heilig, Chad
IR  - Heilig C
FIR - Holmberg, Scott D
IR  - Holmberg SD
FIR - Jamieson, Denise J
IR  - Jamieson DJ
FIR - Moore, Janet S
IR  - Moore JS
FIR - Smith, Dawn K
IR  - Smith DK
FIR - Davenny, Katherine
IR  - Davenny K
EDAT- 2009/12/25 06:00
MHDA- 2010/03/18 06:00
PMCR- 2010/09/01
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/03/18 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - JVI.01962-09 [pii]
AID - 1962-09 [pii]
AID - 10.1128/JVI.01962-09 [doi]
PST - ppublish
SO  - J Virol. 2010 Mar;84(5):2610-7. doi: 10.1128/JVI.01962-09. Epub 2009 Dec 23.