PMID- 20032423
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20091224
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 29
IP  - 11
DP  - 2009 Nov
TI  - Epithelial-myoepithelial carcinoma of the minor salivary glands: 
      immunohistochemical and morphological features.
PG  - 4703-9
AB  - AIMS: Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland 
      neoplasm that most commonly occurs in the parotid gland, but can also arise in 
      the minor salivary glands. Three cases are reported of epithelial-myoepithelial 
      carcinoma of the minor salivary glands, with the goal of better defining this 
      entity. PATIENTS AND METHODS: All three cases showed a characteristic 
      nodular/multinodular growth pattern and classic biphasic tubular histology. All 
      parts of each tumor were surrounded by a myoepithelial cell rim and there was 
      evidence of invasion. RESULTS: Immunohistochemical analysis showed the tumor 
      cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 
      and strongly positive for epithelial membrane antigen (EMA) and p63; they were 
      focally positive for calponin and acute lymphoblastic leukemia antigen (CD10). 
      The tumor cells were negative for vimentin, alpha-smooth muscle actin (SMA) 
      (except one case), glial fibrillar acid protein (GFAP) and MIB1. The tumors were 
      resected completely with wide margins and no recurrence or metastasis had 
      occurred from 6 to 15 months after surgery. CONCLUSION: Three cases of minor 
      salivary gland tumors are described and the differential diagnosis underlined in 
      relation to benign myoepithelioma. The characteristic morphological and 
      immunohistochemical features aided diagnosis of these biphasic tumors.
FAU - Angiero, Francesca
AU  - Angiero F
AD  - Anatomia Patologica, Ospedale San Gerardo Via Pergolesi 33, Monza, Italy. 
      f.angiero@teos.it
FAU - Sozzi, Davide
AU  - Sozzi D
FAU - Seramondi, Rossella
AU  - Seramondi R
FAU - Valente, Maria Gabriella
AU  - Valente MG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Epithelial Cells/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - Keratins/biosynthesis
MH  - Male
MH  - Middle Aged
MH  - Myoepithelioma/metabolism/*pathology
MH  - Salivary Gland Neoplasms/metabolism/*pathology
EDAT- 2009/12/25 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 29/11/4703 [pii]
PST - ppublish
SO  - Anticancer Res. 2009 Nov;29(11):4703-9.