PMID- 20034705
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20181201
IS  - 0210-5691 (Print)
IS  - 0210-5691 (Linking)
VI  - 34
IP  - 8
DP  - 2010 Nov
TI  - [Dendritic cells in sepsis: an approach to post-infectious immunosuppression].
PG  - 559-66
LID - 10.1016/j.medin.2009.11.005 [doi]
AB  - Dendritic cells (DCs) play a decisive role in the immune system, especially in 
      the initial events that determine coordination between the innate and adaptive 
      response. Moreover, they are antigen-presenting cells which, through contact with 
      T cells, determine the type of immune responses towards inflammatory or 
      anti-inflammatory. Currently, the hypothesis that attributes importance to the 
      development of a post-infectious immunosuppression in the prognosis of the septic 
      patient is growing stronger. It has been possible to verify the role played by 
      these cells in this type of immunosuppression by the significant decrease in the 
      number of DCs and by the dysfunctions in the functional capacity that include, on 
      the one hand, the abnormal cytokine production and, on the other hand, the 
      alterations in communication between the DCs and T cells that constitute an 
      essential immunological fact. Further research into the knowledge regarding the 
      DCs, in the context of severe infection, may help to consolidate some encouraging 
      data that indicate these cells as: 1) an effective tool for monitoring the acute 
      infection, 2) a discriminatory variable that may help determine the risk of 
      nosocomial infection and 3) in a longer term, a treatment target that would 
      restore the immunological abnormalities that occur in sepsis.
CI  - Copyright (c) 2009. Published by Elsevier Espana.
FAU - Sirgo, G
AU  - Sirgo G
AD  - UMI, Hospital Verge de la Cinta, Tortosa, Tarragona, Espana. 
      gsirgoluanco@yahoo.es
FAU - Claramonte, R
AU  - Claramonte R
FAU - Chanovas, M
AU  - Chanovas M
FAU - Esteban, F
AU  - Esteban F
FAU - Forcadell, I
AU  - Forcadell I
FAU - Luna, J
AU  - Luna J
FAU - Masdeu, G
AU  - Masdeu G
FAU - Ramon Vazquez, J
AU  - Ramon Vazquez J
FAU - Artigas, A
AU  - Artigas A
LA  - spa
PT  - Journal Article
PT  - Review
TT  - Celulas dendriticas en la sepsis: una aproximacion a la inmunosupresion 
      postinfecciosa.
DEP - 20100114
PL  - Spain
TA  - Med Intensiva
JT  - Medicina intensiva
JID - 9207689
RN  - 0 (Cytokines)
SB  - IM
MH  - Antigen Presentation
MH  - Apoptosis
MH  - Cell Communication
MH  - Cell Count
MH  - Cell Differentiation
MH  - Cross Infection/immunology
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology
MH  - Flow Cytometry
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - Inflammation/immunology
MH  - Lymphocyte Activation
MH  - Sepsis/*immunology/pathology
MH  - T-Lymphocyte Subsets/immunology
EDAT- 2009/12/26 06:00
MHDA- 2011/03/23 06:00
CRDT- 2009/12/26 06:00
PHST- 2009/08/25 00:00 [received]
PHST- 2009/10/16 00:00 [revised]
PHST- 2009/11/08 00:00 [accepted]
PHST- 2009/12/26 06:00 [entrez]
PHST- 2009/12/26 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - S0210-5691(09)00140-5 [pii]
AID - 10.1016/j.medin.2009.11.005 [doi]
PST - ppublish
SO  - Med Intensiva. 2010 Nov;34(8):559-66. doi: 10.1016/j.medin.2009.11.005. Epub 2010 
      Jan 14.