PMID- 20035417
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20211020
IS  - 1867-108X (Electronic)
IS  - 1867-1071 (Linking)
VI  - 27
IP  - 10
DP  - 2009 Dec
TI  - Evaluation of rectal bleeding factors associated with prostate brachytherapy.
PG  - 444-9
LID - 10.1007/s11604-009-0369-5 [doi]
AB  - PURPOSE: To analyze rectal bleeding prognostic factors associated with prostate 
      brachytherapy (PB) or in combination with external-beam radiation therapy (EBRT) 
      and to examine dosimetric indications associated with rectal bleeding. MATERIALS 
      AND METHODS: The study included 296 patients followed up for >36 months (median, 
      48 months). PB was performed alone in 252 patients and in combination with EBRT 
      in 44 patients. PB combined with EBRT is indicated for patients with a Gleason 
      score >6. The prescribed dose was 144 Gy for monotherapy and 110 Gy for PB + EBRT 
      (44-46 Gy). RESULTS: Although 9.1% who received monotherapy had 2.3% grade 2 
      rectal bleeding, 36.3% who received combined therapy had 15.9% grade 2 rectal 
      bleeding. Combined therapy was associated with higher incidence of rectal 
      bleeding (P = 0.0049) and higher percentage of grade 2 bleeding (P = 0.0005). 
      Multivariate analysis revealed that R-150 was the only significant factor for 
      rectal bleeding, and modified Radiation Therapy Oncology Group (RTOG) grade in 
      monotherapy and biologically equivalent dose (BED) were significant for combined 
      therapy. Moreover, grade 2 rectal bleeding increased significantly at D90 > 130 
      Gy. CONCLUSION: Although R-150 was the significant prognostic factor for rectal 
      bleeding and modified RTOG rectal toxicity grade, BED was the significant 
      prognostic factor for modified RTOG rectal toxicity grade.
FAU - Aoki, Manabu
AU  - Aoki M
AD  - Department of Radiology, Jikei University School of Medicine, Tokyo, Japan. 
      maoki@jikei.ac.jp
FAU - Miki, Kenta
AU  - Miki K
FAU - Sasaki, Hiroshi
AU  - Sasaki H
FAU - Kido, Masato
AU  - Kido M
FAU - Shirahama, Jun
AU  - Shirahama J
FAU - Takagi, Sayako
AU  - Takagi S
FAU - Kobayashi, Masao
AU  - Kobayashi M
FAU - Honda, Chikara
AU  - Honda C
FAU - Kanehira, Chihiro
AU  - Kanehira C
LA  - eng
PT  - Journal Article
DEP - 20091225
PL  - Japan
TA  - Jpn J Radiol
JT  - Japanese journal of radiology
JID - 101490689
SB  - IM
MH  - Aged
MH  - Brachytherapy/*adverse effects
MH  - Follow-Up Studies
MH  - Gastrointestinal Hemorrhage/epidemiology/*etiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Prostatic Neoplasms/epidemiology/*radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Conformal/adverse effects
MH  - Rectal Diseases/epidemiology/*etiology
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Tokyo/epidemiology
EDAT- 2009/12/26 06:00
MHDA- 2010/04/03 06:00
CRDT- 2009/12/26 06:00
PHST- 2009/06/21 00:00 [received]
PHST- 2009/08/19 00:00 [accepted]
PHST- 2009/12/26 06:00 [entrez]
PHST- 2009/12/26 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 10.1007/s11604-009-0369-5 [doi]
PST - ppublish
SO  - Jpn J Radiol. 2009 Dec;27(10):444-9. doi: 10.1007/s11604-009-0369-5. Epub 2009 
      Dec 25.