PMID- 20036816
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20220225
IS  - 2768-6698 (Electronic)
IS  - 2768-6698 (Linking)
VI  - 15
IP  - 1
DP  - 2010 Jan 1
TI  - The role of hypoxia and acidosis in promoting metastasis and resistance to 
      chemotherapy.
PG  - 213-25
AB  - By a multiplicity of mechanisms, hypoxia and acidosis create a nurturing 
      environment for tumor progression and the evolution of metastatic, drug-resistant 
      cells. Acidosis drives mutagenesis and promotes the subversion of checkpoints and 
      apoptotic mechanisms. Hypoxic tissues secrete cytokines that undermine normal 
      anti-tumor surveillance by macrophages, turning them into accomplices and 
      facilitators of invasion and angiogenesis. Invasiveness is also abetted by 
      acidosis, the result of shifting to an anaerobic glycolytic metabolism. These 
      factors explain the generally poor prognosis indicated by tumors expressing 
      hypoxia-inducible factor-1 (HIF-1). However, these insights into the physiology 
      of hypoxic tumors have inspired the development of new chemotherapeutic 
      approaches directed at these tissues, including bioreductive drugs and gene 
      therapies, some of which are in clinical trials. The ability to target the 
      hypoxic compartment should allow longer progression-free survival and overall 
      survival of patients bearing solid tumor malignancies.
FAU - DeClerck, Katie
AU  - DeClerck K
AD  - Department of Medical Microbiology, Immunology, and Cell Biology, Southern 
      Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794, USA.
FAU - Elble, Randolph C
AU  - Elble RC
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100101
PL  - Singapore
TA  - Front Biosci (Landmark Ed)
JT  - Frontiers in bioscience (Landmark edition)
JID - 101612996
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Acidosis/*physiopathology
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/therapeutic use
MH  - *Drug Resistance, Neoplasm
MH  - Humans
MH  - Hypoxia/*physiopathology
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Models, Biological
MH  - Neoplasm Metastasis
MH  - Neoplasms/drug therapy/metabolism/*pathology
RF  - 114
EDAT- 2009/12/29 06:00
MHDA- 2010/04/24 06:00
CRDT- 2009/12/29 06:00
PHST- 2009/12/29 06:00 [entrez]
PHST- 2009/12/29 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - 3616 [pii]
AID - 10.2741/3616 [doi]
PST - epublish
SO  - Front Biosci (Landmark Ed). 2010 Jan 1;15(1):213-25. doi: 10.2741/3616.