PMID- 20037169
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20220408
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Apr
TI  - Incidence and outcome of patients starting renal replacement therapy for 
      end-stage renal disease due to multiple myeloma or light-chain deposit disease: 
      an ERA-EDTA Registry study.
PG  - 1200-6
LID - 10.1093/ndt/gfp679 [doi]
AB  - BACKGROUND: Information on demographics and survival of patients starting renal 
      replacement therapy (RRT) for end-stage renal disease (ESRD) due to multiple 
      myeloma (MM) or light-chain deposit disease (LCDD) is scarce. The aim of this 
      study was to describe the incidence, characteristics, causes of death and 
      survival rates of RRT for ESRD due to MM or LCDD in the ERA-EDTA Registry. 
      METHODS: Thirteen national registries providing data on patients who started RRT 
      from 1986-2005 to the ERA-EDTA Registry participated. Incidence per million 
      population (pmp) of RRT for ESRD due to MM or LCDD and other causes (non-MM) was 
      observed overtime. Patient survival on RRT was examined, unadjusted and adjusted 
      for age and gender. RESULTS: Of the 159 637 patients on RRT, 2453 (1.54%) had MM 
      or LCDD. The incidence of RRT for ESRD due to MM or LCDD, adjusted for age and 
      gender, increased from 0.70 pmp in 1986-1990 to 2.52 pmp in 2001-2005. MM and 
      LCDD patients compared to non-MM patients were older and a higher percentage was 
      on haemodialysis at day 91 after the start of RRT. The most common causes of 
      death in MM and LCDD patients were malignancy (36.1%), cardiovascular causes 
      (17.2%) and infection (14.7%). MM and LCDD patients had a 2.77 (95% CI, 
      2.65-2.90) higher risk of death compared to non-MM patients. The unadjusted 
      median survival on RRT was 0.91 years in MM and LCDD patients and 4.46 years in 
      non-MM patients. During follow-up, 35 patients were transplanted and their mean 
      survival was 9.6 years. CONCLUSION: The incidence of RRT for ESRD due to MM or 
      LCDD has increased over the past 20 years in Europe. The median patient survival 
      on RRT for MM and LCDD patients was 0.91 years, compared to 4.46 years for non-MM 
      patients. These results suggest that dialysis, and in selected cases even 
      transplantation, should be offered to MM and LCDD patients.
FAU - Tsakiris, Dimitrios J
AU  - Tsakiris DJ
AD  - Department of Nephrology, General Hospital Papageorgiou of Thessaloniki, Greece. 
      dimtsak@otenet.gr
FAU - Stel, Vianda S
AU  - Stel VS
FAU - Finne, Patrik
AU  - Finne P
FAU - Fraser, Emily
AU  - Fraser E
FAU - Heaf, James
AU  - Heaf J
FAU - de Meester, Johan
AU  - de Meester J
FAU - Schmaldienst, Sabine
AU  - Schmaldienst S
FAU - Dekker, Friedo
AU  - Dekker F
FAU - Verrina, Enrico
AU  - Verrina E
FAU - Jager, Kitty J
AU  - Jager KJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20091227
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
CIN - Nephrol Dial Transplant. 2010 Aug;25(8):2799. PMID: 20501461
MH  - Age Factors
MH  - Aged
MH  - Cause of Death
MH  - Female
MH  - Humans
MH  - *Immunoglobulin Light Chains
MH  - Incidence
MH  - International Agencies
MH  - Kidney Failure, Chronic/*etiology/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*complications/mortality
MH  - Paraproteinemias/*complications/mortality
MH  - Registries
MH  - *Renal Replacement Therapy
MH  - Risk Factors
MH  - Survival Rate
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2009/12/29 06:00
MHDA- 2010/08/18 06:00
CRDT- 2009/12/29 06:00
PHST- 2009/12/29 06:00 [entrez]
PHST- 2009/12/29 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - gfp679 [pii]
AID - 10.1093/ndt/gfp679 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2010 Apr;25(4):1200-6. doi: 10.1093/ndt/gfp679. Epub 
      2009 Dec 27.