PMID- 20038536
OWN - NLM
STAT- MEDLINE
DCOM- 20100326
LR  - 20211020
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Print)
IS  - 0019-9567 (Linking)
VI  - 78
IP  - 3
DP  - 2010 Mar
TI  - Associations between mucosal innate and adaptive immune responses and resolution 
      of diarrheal pathogen infections.
PG  - 1221-8
LID - 10.1128/IAI.00767-09 [doi]
AB  - The identification of immune response mechanisms that contribute to the control 
      of diarrheal disease in developing countries remains an important priority. We 
      addressed the role of fecal chemokines and cytokines in the resolution of 
      diarrheal Escherichia coli and Giardia lamblia infections. Stools collected from 
      127 Mexican children 5 to 15 months of age enrolled in a randomized, 
      double-blind, placebo-controlled, vitamin A supplementation trial were screened 
      for enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli (ETEC), and 
      Giardia lamblia. Fecal concentrations of tumor necrosis factor alpha (TNF-alpha), 
      monocyte chemoattractant protein-1 (MCP-1), interleukin-4 (IL-4), IL-5, IL-6, 
      IL-8, IL-10, and interferon-gamma (IFN-gamma) were determined. Hazard models 
      incorporating cytokine variables were fit to durations of asymptomatic and 
      symptomatic pathogen infections, controlling for treatment group. Increased 
      levels of TNF-alpha and IL-6 were associated with decreased durations of EPEC 
      infection and increased ETEC durations. Increased IL-4 and IFN-gamma levels were 
      associated with decreased and increased durations, respectively, of both EPEC and 
      ETEC infections. Increased IL-10 levels were associated with increased and 
      decreased durations of asymptomatic and symptomatic EPEC infections, 
      respectively, and increased durations of both asymptomatic and symptomatic ETEC 
      infections. Increased levels of MCP-1, IFN-gamma, IL-4, and IL-5 were associated 
      with increased G. lamblia infection duration, while increased IL-8 levels were 
      associated with decreased durations. Differences in proinflammatory and Treg 
      cytokine levels are associated with differences in the resolution of inflammatory 
      and noninflammatory pathogen infections.
FAU - Long, Kurt Z
AU  - Long KZ
AD  - Nutrition Environmental Health and Disease and Injury Control Unit, The 
      University of Queensland, School of Population Health, Herston Rd., Herston, 
      Queensland 4006, Australia. k.long@uq.edu.au
FAU - Rosado, Jorge L
AU  - Rosado JL
FAU - Santos, Jose Ignacio
AU  - Santos JI
FAU - Haas, Meredith
AU  - Haas M
FAU - Al Mamun, Abdullah
AU  - Al Mamun A
FAU - DuPont, Herbert L
AU  - DuPont HL
FAU - Nanthakumar, Nanda N
AU  - Nanthakumar NN
FAU - Estrada-Garcia, Teresa
AU  - Estrada-Garcia T
LA  - eng
GR  - P30 DK040561/DK/NIDDK NIH HHS/United States
GR  - P30 DK040561-14/DK/NIDDK NIH HHS/United States
GR  - K01 DK06142-02/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091228
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Cytokines)
RN  - 11103-57-4 (Vitamin A)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Cytokines/analysis
MH  - Diarrhea/*immunology
MH  - Enteritis/*immunology
MH  - Escherichia coli/*immunology
MH  - Escherichia coli Infections/*immunology
MH  - Feces/chemistry
MH  - Giardia lamblia/*immunology
MH  - Giardiasis/*immunology
MH  - Humans
MH  - Immunity, Innate
MH  - *Immunity, Mucosal
MH  - Infant
MH  - Mexico
MH  - Randomized Controlled Trials as Topic
MH  - T-Lymphocytes/immunology
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Vitamin A/administration & dosage
PMC - PMC2825919
EDAT- 2009/12/30 06:00
MHDA- 2010/03/27 06:00
PMCR- 2010/09/01
CRDT- 2009/12/30 06:00
PHST- 2009/12/30 06:00 [entrez]
PHST- 2009/12/30 06:00 [pubmed]
PHST- 2010/03/27 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - IAI.00767-09 [pii]
AID - 0767-09 [pii]
AID - 10.1128/IAI.00767-09 [doi]
PST - ppublish
SO  - Infect Immun. 2010 Mar;78(3):1221-8. doi: 10.1128/IAI.00767-09. Epub 2009 Dec 28.