PMID- 20039801
OWN - NLM
STAT- MEDLINE
DCOM- 20100127
LR  - 20211020
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 201
IP  - 3
DP  - 2010 Feb 1
TI  - A case of seronegative HIV-1 infection.
PG  - 341-5
LID - 10.1086/649822 [doi]
AB  - Patients infected with human immunodeficiency virus type 1 (HIV-1) typically 
      seroconvert within weeks of primary infection. In rare cases, patients do not 
      develop antibodies against HIV-1 despite demonstrable infection. We describe here 
      a human leukocyte antigen (HLA)-B*5802-positive individual who presented with 
      acquired immune deficiency syndrome despite repeatedly negative HIV-1 antibody 
      screening test results. Phylogenetic analysis of env clones revealed little 
      sequence diversity, and weak HIV-1-specific CD8(+) T cell responses were present 
      to Gag epitopes. The patient seroconverted after immune reconstitution during 
      receipt of highly active antiretroviral therapy. Lack of an antibody response to 
      HIV-1 is rare and appears to be due to a defect in HIV-1-specific immunity rather 
      than infection with attenuated virus.
FAU - Spivak, Adam M
AU  - Spivak AM
AD  - Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland, USA. jblanks@jhmi.edu
FAU - Brennan, Tim P
AU  - Brennan TP
FAU - O'Connell, Karen A
AU  - O'Connell KA
FAU - Sydnor, Emily
AU  - Sydnor E
FAU - Williams, Thomas M
AU  - Williams TM
FAU - Siliciano, Robert F
AU  - Siliciano RF
FAU - Gallant, Joel E
AU  - Gallant JE
FAU - Blankson, Joel N
AU  - Blankson JN
LA  - eng
GR  - R01 AI080328/AI/NIAID NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R56 AI073185/AI/NIAID NIH HHS/United States
GR  - R01 AI080328-01A2/AI/NIAID NIH HHS/United States
GR  - R56 AI73185-01A1/AI/NIAID NIH HHS/United States
GR  - R56 AI073185-01A1/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Gene Products, env)
RN  - 0 (HIV Antibodies)
SB  - IM
MH  - Base Sequence
MH  - Gene Products, env/genetics
MH  - HIV Antibodies/*blood
MH  - HIV Infections/*blood/immunology
MH  - HIV Seronegativity/*immunology
MH  - HIV-1/genetics/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC2821828
MID - NIHMS158279
COIS- The authors report no conflict of interest.
EDAT- 2009/12/31 06:00
MHDA- 2010/01/28 06:00
PMCR- 2011/02/01
CRDT- 2009/12/31 06:00
PHST- 2009/12/31 06:00 [entrez]
PHST- 2009/12/31 06:00 [pubmed]
PHST- 2010/01/28 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - 10.1086/649822 [doi]
PST - ppublish
SO  - J Infect Dis. 2010 Feb 1;201(3):341-5. doi: 10.1086/649822.