PMID- 20040347
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20190608
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 73
IP  - 1
DP  - 2010 Jan
TI  - The relationship between serum level of N-terminal pro-B-type natriuretic peptide 
      and nutritional status, and inflammation in chronic hemodialysis patients.
PG  - 14-20
AB  - BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-pro BNP), a biomarker 
      of heart failure, is involved in regulation of the body fluid homeostasis and 
      vascular tone. The purpose of this study was to investigate the relationship 
      between serum level of NT-pro BNP and nutritional status, inflammation and 
      hydration in patients on maintenance hemodialysis (HD). MATERIALS AND METHODS: 
      The study involved 97 HD patients (mean age: 65.3 +/- 13.9 years, HD duration: 
      36.3 +/- 43.5 months). Blood tests comprised the measurements of serum levels of 
      NT-pro BNP, interleukin-6 (IL-6), human soluble tumor necrosis factor receptor I 
      (s TNF RI), hemoglobin (Hb), albumin (alb) and urea. Furthermore, normalized 
      protein catabolic rate (n PCR), body mass index (BMI), mean arterial blood 
      pressure (MAP), adequacy of HD (Kt/V), and interdialytic body weight gain (IBWG) 
      were calculated. In addition, NT-pro BNP was measured in a healthy control group 
      (CG; n = 24, mean age 49.5 +/- 15.0 years). Hydration status was determined by 
      bioimpedance analysis (BIA). RESULTS: Irrespective of gender, NT-pro BNP levels 
      were markedly elevated in HD patients compared with CG (15879.2 +/- 14033.3 pg/ml 
      vs. 73.45 +/- 23.56 pg/ml; p < 0.00001). NT-pro BNP was unrelated to any measures 
      of body fluid compartments. Multivariate regression analysis revealed that only 
      four parameters (nPCR, Hb, MAP, and total time on HD) influenced serum NT-pro BNP 
      levels. CONCLUSION: While there was only moderate direct association of NT-pro 
      BNP with hydration status, it was elevated in patients with intensive catabolism, 
      severe anemia, higher MAP and longer total duration of HD.
FAU - Bednarek-Skublewska, A
AU  - Bednarek-Skublewska A
AD  - Department of Nephrology, Medical University of Lublin, Poland. 
      anna.bednarek@diaverum.com
FAU - Zaluska, W
AU  - Zaluska W
FAU - Ksiazek, A
AU  - Ksiazek A
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (ALB protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Hemoglobins)
RN  - 0 (Interleukin-6)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Serum Albumin)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - ZIF514RVZR (Serum Albumin, Human)
SB  - IM
MH  - Aged
MH  - Body Water/metabolism
MH  - Female
MH  - Glycoproteins/blood
MH  - Hemoglobins/metabolism
MH  - Homeostasis
MH  - Humans
MH  - Inflammation/*blood
MH  - Interleukin-6/blood
MH  - Kidney Failure, Chronic/*therapy
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - *Nutritional Status
MH  - Peptide Fragments/*blood
MH  - Receptors, Tumor Necrosis Factor, Type I/blood
MH  - Regression Analysis
MH  - *Renal Dialysis
MH  - Serum Albumin
MH  - Serum Albumin, Human
MH  - Sex Factors
MH  - Spectrum Analysis
EDAT- 2009/12/31 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/12/31 06:00
PHST- 2009/12/31 06:00 [entrez]
PHST- 2009/12/31 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 7226 [pii]
AID - 10.5414/cnp73014 [doi]
PST - ppublish
SO  - Clin Nephrol. 2010 Jan;73(1):14-20. doi: 10.5414/cnp73014.