PMID- 20041967
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20211020
IS  - 1751-553X (Electronic)
IS  - 1751-5521 (Print)
IS  - 1751-5521 (Linking)
VI  - 32
IP  - 4
DP  - 2010 Aug 1
TI  - Myelodysplastic syndrome in elderly patients: correlation of CBC with cytogenetic 
      and FISH analysis.
PG  - 443-8
LID - 10.1111/j.1751-553X.2009.01210.x [doi]
AB  - Unexplained anemia in the elderly could represent myelodysplastic syndrome (MDS). 
      We assessed the utility of using a fluorescence in situ hybridization (FISH) 
      panel for common chromosomal abnormalities seen in MDS. A total of 101 elderly 
      outpatients with anemia of unknown etiology were evaluated. Complete blood count, 
      bone marrow biopsy, conventional cytogenetic analysis (CC), and FISH panel were 
      reviewed. A total of 21 (21%) of the 101 patients had MDS. A combination of CC 
      and FISH identified chromosomal abnormalities in 17 (81%) of the patients with 
      MDS. The remaining 4 (19%) were diagnosed with MDS based solely on morphologic 
      criteria. Except in two cases, FISH did not reveal abnormalities not already 
      detected by CC. Furthermore, MDS patients infrequently had isolated anemia (14%) 
      as opposed to those without MDS (75%). A MDS FISH panel is not more sensitive 
      than CC in elderly outpatients with unexplained anemia. MDS is more likely if in 
      addition to anemia, leukopenia and/or thrombocytopenia are also present.
FAU - Codispoti, K-E T
AU  - Codispoti KE
AD  - Department of Pathology, The George Washington University Medical Center, NW, 
      Washington, DC, USA. kcodisp1@jhmi.edu
FAU - Depalma, L
AU  - Depalma L
LA  - eng
GR  - T32 EB006351/EB/NIBIB NIH HHS/United States
GR  - T32 EB006351-04/EB/NIBIB NIH HHS/United States
PT  - Journal Article
DEP - 20091223
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia/diagnosis/genetics
MH  - Blood Cell Count
MH  - *Chromosome Aberrations
MH  - *Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Myelodysplastic Syndromes/*blood/diagnosis/*genetics
PMC - PMC2897924
MID - NIHMS169134
EDAT- 2010/01/01 06:00
MHDA- 2011/01/15 06:00
PMCR- 2010/08/01
CRDT- 2010/01/01 06:00
PHST- 2010/01/01 06:00 [entrez]
PHST- 2010/01/01 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
PHST- 2010/08/01 00:00 [pmc-release]
AID - CLH1210 [pii]
AID - 10.1111/j.1751-553X.2009.01210.x [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2010 Aug 1;32(4):443-8. doi: 10.1111/j.1751-553X.2009.01210.x. 
      Epub 2009 Dec 23.