PMID- 20042517
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20211020
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 17
IP  - 3
DP  - 2010 Mar
TI  - Immunogenicity of a heptavalent conjugate pneumococcal vaccine administered 
      concurrently with a combination diphtheria, tetanus, five-component acellular 
      pertussis, inactivated polio, and Haemophilus influenzae type B vaccine and a 
      meningococcal group C conjugate vaccine at 2, 3, and 4 months of age.
PG  - 311-6
LID - 10.1128/CVI.00315-09 [doi]
AB  - The immunogenicities of conjugate pneumococcal vaccines have been demonstrated 
      when they are administered at 2, 3, and 4 months of age. There is a paucity of 
      data on the immunogenicity of this vaccine when it is administered concurrently 
      with other vaccines in the primary immunization schedule of the United Kingdom. 
      We immunized 55 term infants at 2, 3, and 4 months of age with the seven-valent 
      pneumococcal conjugate vaccine (PCV7), the meningococcal group C conjugate (MCC) 
      vaccine, and the diphtheria, tetanus, five-component acellular pertussis, 
      inactivated polio, and Haemophilus influenzae type b (DTaP(5)/IPV/Hib-TT) 
      vaccine. The immune responses to the H. influenzae type b (Hib), MCC, and tetanus 
      vaccines were measured at 2, 5, and 12 months of age; and the immune responses to 
      PCV7 were measured at 2 and 5 months and then either at 12 months or following a 
      4th dose of PCV7. There were increases in the geometric mean concentrations 
      (GMCs) of all antigens postimmunization. Greater than or equal to 90% of the 
      infants achieved putatively protective levels postimmunization for all vaccine 
      antigens except pneumococcal serotype 6B and Hib. The GMCs of the PCV7 serotypes 
      increased following a 4th dose, although one infant had not reached putative 
      levels of protection against serotype 6B. In conclusion, when infants were 
      vaccinated according to the schedule described above, they had lower postprimary 
      immunization responses to Hib, meningococcus group C capsular polysaccharide, and 
      pneumococcal serotype 6B than the responses demonstrated by use of the other 
      schedules. Despite this finding, there was a good response following a 4th dose 
      of PCV7.
FAU - Moss, S J
AU  - Moss SJ
AD  - Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, UK. 
      samanthajmoss@doctors.org.uk
FAU - Fenton, A C
AU  - Fenton AC
FAU - Toomey, J
AU  - Toomey J
FAU - Grainger, A
AU  - Grainger A
FAU - Borrow, R
AU  - Borrow R
FAU - Balmer, P
AU  - Balmer P
FAU - Smith, J
AU  - Smith J
FAU - Gennery, A R
AU  - Gennery AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091230
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Diphtheria-Tetanus-acellular Pertussis Vaccines)
RN  - 0 (Haemophilus Vaccines)
RN  - 0 (Meningococcal Vaccines)
RN  - 0 (Pneumococcal Vaccines)
RN  - 0 (Poliovirus Vaccines)
RN  - 0 (Vaccines, Combined)
SB  - IM
MH  - Antibodies, Bacterial/blood
MH  - Antibodies, Viral/blood
MH  - Diphtheria-Tetanus-acellular Pertussis Vaccines/administration & 
      dosage/*immunology
MH  - Haemophilus Vaccines/administration & dosage/*immunology
MH  - Humans
MH  - *Immunization Schedule
MH  - Immunization, Secondary
MH  - Infant
MH  - Meningococcal Vaccines/administration & dosage/*immunology
MH  - Pneumococcal Vaccines/administration & dosage/*immunology
MH  - Poliovirus Vaccines/administration & dosage/*immunology
MH  - Vaccines, Combined/immunology
PMC - PMC2837965
EDAT- 2010/01/01 06:00
MHDA- 2010/05/21 06:00
PMCR- 2010/09/01
CRDT- 2010/01/01 06:00
PHST- 2010/01/01 06:00 [entrez]
PHST- 2010/01/01 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - CVI.00315-09 [pii]
AID - 0315-09 [pii]
AID - 10.1128/CVI.00315-09 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2010 Mar;17(3):311-6. doi: 10.1128/CVI.00315-09. Epub 2009 
      Dec 30.