PMID- 20043329
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20211020
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 33
IP  - 2
DP  - 2010 Feb
TI  - Serum cardiac troponin I is related to increased left ventricular wall thickness, 
      left ventricular dysfunction, and male gender in hypertrophic cardiomyopathy.
PG  - E1-7
LID - 10.1002/clc.20622 [doi]
AB  - BACKGROUND: Serum cardiac troponin I (cTnI) is a sensitive and specific marker of 
      myocardial injury. However, a systematic evaluation of cTnI in hypertrophic 
      cardiomyopathy (HCM) patients has not been performed. HYPOTHESIS: The purpose of 
      this study is to evaluate cTnI and determine its relationship to clinical 
      features in HCM. METHODS: We studied serum cTnI in 162 consecutive HCM patients. 
      RESULTS: Serum cTnI ranged from 0.01 to 0.83 ng/mL (mean, 0.068 +/- 0.100 ng/mL) 
      and was higher in male patients (P < .001), those with atrial fibrillation (P = 
      .033), and left ventricular (LV) systolic dysfunction (P = .046). Serum cTnI 
      values were also correlated with maximum LV wall thickness (r = 0.30, P < .001), 
      LV end-systolic diameter (r = 0.20, P = .012), and E/Ea (peak early transmitral 
      filling velocity/early diastolic mitral annulus velocity; r = 0.24, P = .004). 
      Serum cTnI levels were not significantly different among New York Heart 
      Association (NYHA) functional class and there was no difference between patients 
      with or without LV outflow tract obstruction; although B-type natriuretic peptide 
      (BNP) levels showed significant difference in those variables. Serum cTnI had 
      very weak correlation with BNP values (r = 0.18, P = .023). Multivariate analysis 
      revealed an independent relationship between cTnI and maximum LV wall thickness, 
      E/Ea, and male gender. CONCLUSIONS: In patients with HCM, serum cTnI was 
      associated with important clinical indices such as maximum LV wall thickness, LV 
      dysfunction, and male gender. Serum cTnI seemed to have clinical significance 
      different from that of BNP and may not be reflecting cardiac load but the LV 
      remodeling process in HCM.
CI  - Copyright 2010 Wiley Periodicals, Inc.
FAU - Kubo, Toru
AU  - Kubo T
AD  - Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan.
FAU - Kitaoka, Hiroaki
AU  - Kitaoka H
FAU - Okawa, Makoto
AU  - Okawa M
FAU - Yamanaka, Shigeo
AU  - Yamanaka S
FAU - Hirota, Takayoshi
AU  - Hirota T
FAU - Hoshikawa, Eri
AU  - Hoshikawa E
FAU - Hayato, Kayo
AU  - Hayato K
FAU - Yamasaki, Naohito
AU  - Yamasaki N
FAU - Matsumura, Yoshihisa
AU  - Matsumura Y
FAU - Yasuda, Nobufumi
AU  - Yasuda N
FAU - Sugiura, Tetsuro
AU  - Sugiura T
FAU - Doi, Yoshinori L
AU  - Doi YL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Biomarkers)
RN  - 0 (Troponin I)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Hypertrophic/*blood/diagnostic imaging/physiopathology
MH  - Chi-Square Distribution
MH  - Child
MH  - Cross-Sectional Studies
MH  - Echocardiography, Doppler
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*blood/diagnostic imaging/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Predictive Value of Tests
MH  - Regression Analysis
MH  - Sex Factors
MH  - Troponin I/*blood
MH  - Up-Regulation
MH  - Ventricular Dysfunction, Left/*blood/diagnostic imaging/physiopathology
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
MH  - Young Adult
PMC - PMC6653149
EDAT- 2010/01/01 06:00
MHDA- 2010/07/23 06:00
PMCR- 2009/12/30
CRDT- 2010/01/01 06:00
PHST- 2010/01/01 06:00 [entrez]
PHST- 2010/01/01 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PHST- 2009/12/30 00:00 [pmc-release]
AID - CLC20622 [pii]
AID - 10.1002/clc.20622 [doi]
PST - ppublish
SO  - Clin Cardiol. 2010 Feb;33(2):E1-7. doi: 10.1002/clc.20622.