PMID- 20043559
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20100101
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 92
IP  - 12
DP  - 2009 Dec
TI  - Feasibility and safety of intra-coronary bone marrow mononuclear cell 
      transplantation in ST elevation myocardial infarction patients.
PG  - 1591-6
AB  - BACKGROUND: Stem cell transplantation is a potential treatment to improve left 
      ventricular ejection fraction (LVEF) after ST elevation myocardial infarction 
      (STEMI). However technique and mode of transplantation, type of cells, number of 
      cells, and when to transplant are still unknown. OBJECTIVE: To determine the 
      feasibility and safety of bone marrow mononuclear cell (BMC) intra-coronary 
      transplantation and 6-months results in patients with STEMI. MATERIAL AND METHOD: 
      After successful percutaneous coronary intervention (PCI) in STEMI patients who 
      did not have flow re-established within 12 hours and poor LVEF (less than 50%) by 
      echocardiography were enrolled Bone marrow aspiration of 100 cc was performed in 
      the morning. After cell processing for 3 hours, the suspension of BMC about 10 cc 
      were infused to infarcted area using standard PCI technique. Balloon occlusion 
      for 3 minutes was performed during cell infusion. Cardiac magnetic resonance 
      imaging was used to determine LVEF scar volume and LV volume before and 6 months 
      after transplantation. RESULTS: Five patients were enrolled between May and 
      August 2006. Duration of STEMI before transplantation ranged from 18 days to 14 
      years. Total amount of BMC ranged from 67 x 10(6) to 335 x 10(6). Number of CD 34 
      and CD 133+ cells were approximation to be 0.7 x 10(6) to 7.7 x 10(6) and 0.01 x 
      10(6) to 3.04 x 10(6). LVEF was increased from 36.4 at baseline to 43.3 at 
      6-month. NT pro-BNP level was decreased from 1105 ng/ml at baseline to 288 pg/ml 
      at 6-month. No complications such as chest pain, no re-flow phenomenon, 
      ventricular arrhythmia, or hypotension was detected during the procedure. 
      CONCLUSION: Intra-coronary BMC transplantation in patients with STEMI in our 
      center is feasible and safe. LVEF was slightly improved; however, a randomized 
      controlled study is needed.
FAU - Srimahachota, Suphot
AU  - Srimahachota S
AD  - Division of Cardiovascular Diseases, Department of Medicine, King Chulalongkorn 
      Memorial Hospital, Bangkok 10330, Thailand. s_srimahachota@yahoo.co.th
FAU - Boonyaratavej, Smonporn
AU  - Boonyaratavej S
FAU - Rerkpattanapipat, Pairoj
AU  - Rerkpattanapipat P
FAU - Wangsupachart, Somjai
AU  - Wangsupachart S
FAU - Tumkosit, Monravee
AU  - Tumkosit M
FAU - Bunworasate, Udomsak
AU  - Bunworasate U
FAU - Nakorn, Thayapong Na
AU  - Nakorn TN
FAU - Intragumtornchai, Tanin
AU  - Intragumtornchai T
FAU - Kupatawinturn, Pawinee
AU  - Kupatawinturn P
FAU - Pongam, Sunisa
AU  - Pongam S
FAU - Saengsiri, Aem-orn
AU  - Saengsiri AO
FAU - Pothisri, Mantana
AU  - Pothisri M
FAU - Sukseri, Yeesoon
AU  - Sukseri Y
FAU - Bunprasert, Tanorm
AU  - Bunprasert T
FAU - Suithichaiyakul, Taworn
AU  - Suithichaiyakul T
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Angioplasty, Balloon, Coronary
MH  - Bone Marrow Transplantation/*adverse effects/statistics & numerical data
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Leukocytes, Mononuclear/transplantation
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/physiopathology/*therapy
MH  - Natriuretic Peptide, Brain
MH  - Peptide Fragments
MH  - Stroke Volume
MH  - Thailand
MH  - Ventricular Function, Left
EDAT- 2010/01/02 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/01/02 06:00
PHST- 2010/01/02 06:00 [entrez]
PHST- 2010/01/02 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2009 Dec;92(12):1591-6.