PMID- 20043974
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20131121
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 470
IP  - 1
DP  - 2010 Feb 5
TI  - Depression-like state in maternal rats induced by repeated separation of pups is 
      accompanied by a decrease of cell proliferation and an increase of apoptosis in 
      the hippocampus.
PG  - 86-90
LID - 10.1016/j.neulet.2009.12.063 [doi]
AB  - Stressful experiences, such as an unsatisfactory mother-infant relationship after 
      delivery, can induce depressive disorders, and it is well-known that stressors 
      impair memory function. The hippocampus plays a crucial role in memory processes. 
      In the present study, we determined whether a depressed-like state induced by 
      repeated separation of pups affects the memory capability of the maternal rats. 
      We also determined the effects of repeated separation from pups on cell 
      proliferation, apoptosis, and serotonin expression in the brains of maternal 
      rats. In the present results, the immobility time in the forced swim test was 
      increased and the climbing time was decreased in the mothers separated from their 
      pups. The latency in the step-down avoidance task was increased in the mothers 
      separated from their pups. Also, the expressions of serotonin 
      (5-hydroxytryptamine) and tryptophan hydroxylase in the dorsal raphe were 
      decreased in the mothers separated from their pups. The number of Ki-67-positive 
      cells was decreased, while the number of terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL)-positive cells in the 
      hippocampal dentate gyrus was increased in the mothers separated from their pups. 
      Based on the present results, it is suggested that separation of pups might 
      induce a depressed-like state in the maternal rats with reduced cell 
      proliferation and increased apoptosis in the hippocampus, resulting in memory 
      impairment of maternal rats.
CI  - (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Sung, Yun-Hee
AU  - Sung YH
AD  - Department of Physiology, College of Medicine, Kyung Hee University, #1 
      Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
FAU - Shin, Mal-Soon
AU  - Shin MS
FAU - Cho, Sehyung
AU  - Cho S
FAU - Baik, Hyung-Hwan
AU  - Baik HH
FAU - Jin, Byung-Kwan
AU  - Jin BK
FAU - Chang, Hyun-Kyung
AU  - Chang HK
FAU - Lee, Eun-Kyu
AU  - Lee EK
FAU - Kim, Chang-Ju
AU  - Kim CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091230
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Ki-67 Antigen)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - *Cell Proliferation
MH  - Dentate Gyrus/physiopathology
MH  - Depressive Disorder/etiology/*physiopathology
MH  - Female
MH  - Hippocampus/*physiopathology
MH  - In Situ Nick-End Labeling
MH  - Ki-67 Antigen/metabolism
MH  - *Maternal Deprivation
MH  - Memory/physiology
MH  - Memory Disorders/physiopathology
MH  - Mothers
MH  - Random Allocation
MH  - Raphe Nuclei/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Tryptophan Hydroxylase/metabolism
EDAT- 2010/01/02 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/01/02 06:00
PHST- 2009/10/13 00:00 [received]
PHST- 2009/12/02 00:00 [revised]
PHST- 2009/12/22 00:00 [accepted]
PHST- 2010/01/02 06:00 [entrez]
PHST- 2010/01/02 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - S0304-3940(09)01657-7 [pii]
AID - 10.1016/j.neulet.2009.12.063 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Feb 5;470(1):86-90. doi: 10.1016/j.neulet.2009.12.063. Epub 
      2009 Dec 30.