PMID- 20047512
OWN - NLM
STAT- MEDLINE
DCOM- 20100122
LR  - 20191210
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 19
IP  - 9
DP  - 2009 Nov
TI  - Quantitative determination of 3,4-methylenedioxymethamphetamine by thin-layer 
      chromatography in ecstasy illicit pills in Tehran.
PG  - 565-9
LID - 10.3109/15376510903358341 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is the major ingredient of ecstasy 
      illicit pills. It is a hallucinogen, central nervous system stimulant, and 
      serotonergic neurotoxin that strongly releases serotonin from serotonergic nerves 
      terminals. Moreover, it releases norepinephrine and dopamine from nerves 
      terminal, but to a lesser extent than serotonin. Poisoning and even death from 
      abusing MDMA-containing ecstasy illicit pills among abusers is usual. Thus, 
      quantitative determination of MDMA content of ecstasy illicit pills in illicit 
      drug bazaar must be done regularly to find the most high dose ecstasy illicit 
      pills and removing them from illicit drug bazaar. In the present study, MDMA 
      contents of 13 most abundant ecstasy illicit pills were determined by 
      quantitative thin-layer chromatography (TLC). Two procedures for quantitative 
      determination of MDMA contents of ecstasy illicit pills by TLC were used: 
      densitometric and so-called 'scraping off' methods. The former was done in a 
      reflection mode at 285 nm and the latter was done by absorbance measurement of 
      eluted scraped off spots. Limit of detection (LOD), considering signal-to-noise 
      ratio (S/N) of 2, and limit of quantification (LOQ), regarding S/N of 10, of 
      densitometric and scraping off methods were 0.40 microg, 1.20 microg, and 6.87 
      mug, 20.63 microg, respectively. Repeatabilities (within-laboratory error) of 
      densitometric and scraping off methods were 0.5% and 3.6%, respectively. The 
      results showed that the ecstasy illicit pills contained 24-124.5 mg and 
      23.9-122.2 mg MDMA by densitometric and scraping off methods, respectively.
FAU - Shetab Boushehri, Seyed Vahid
AU  - Shetab Boushehri SV
AD  - Department of Medical Nanotechnology, College of Medicine, Iran University of 
      Medical Sciences, Tehran, I.R. Iran.
FAU - Tamimi, Maryam
AU  - Tamimi M
FAU - Kebriaeezadeh, Abbas
AU  - Kebriaeezadeh A
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
RN  - 0 (Illicit Drugs)
RN  - 0 (Tablets)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Chromatography, Thin Layer/*methods
MH  - Illicit Drugs/*analysis
MH  - Iran
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - Tablets
EDAT- 2010/01/06 06:00
MHDA- 2010/01/23 06:00
CRDT- 2010/01/06 06:00
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2010/01/23 06:00 [medline]
AID - 10.3109/15376510903358341 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2009 Nov;19(9):565-9. doi: 10.3109/15376510903358341.