PMID- 20047643
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 75
IP  - 3
DP  - 2010 Mar
TI  - Norwegian Sami differs significantly from other Norwegians according to their HLA 
      profile.
PG  - 207-17
LID - 10.1111/j.1399-0039.2009.01425.x [doi]
AB  - This study reports extensive genomic data for both human leukocyte antigen (HLA) 
      class I and II loci in Norwegian Sami, a native population living in the 
      northwest of Europe. The Sami have a distinct culture and their own languages, 
      which belong to the Uralic linguistic family. Norwegian Sami (n = 200) were typed 
      at the DNA level for the HLA-A, -C, -B, -DRB1 and -DQB1 loci, and compared with a 
      non-Sami Norwegian population (n = 576). The two populations exhibited some 
      common genetic features but also differed significantly at all HLA loci. The most 
      significantly deviating allele frequencies were an increase of HLA-A*03, -B*27, 
      -DRB1*08 and -DQB1*04 and a decrease of HLA-A*01, C*01, -DRB1*04 and -DQB1*02 
      among Sami compared with non-Sami Norwegians. The Sami showed no deviation from 
      Hardy-Weinberg equilibrium. The hypothesis of selective neutrality was rejected 
      at all loci except for the A- and C- loci for the Sami. HLA haplotype frequencies 
      also differed between the two populations. The most common extended HLA 
      haplotypes were A*02-B*27-C*01-DR*08-DQB1*04 in the Sami and 
      A*01-B*08-C*07-DR*03-DQB1*02 in the other Norwegians. Genetic distance analyses 
      indicated that the Norwegian Sami were highly differentiated from other Europeans 
      and were most closely related to Finns whose language also belongs to the Uralic 
      linguistic family. In conclusion, the Norwegian Sami and the non-Sami Norwegians 
      were significantly different at all HLA loci. Our results can be explained by the 
      fact that the two populations have different origins and that the Sami population 
      has remained smaller and more isolated than its neighbors.
FAU - Harbo, H F
AU  - Harbo HF
AD  - Department of Neurology, Oslo University Hospital, Ulleval, Oslo, Norway. 
      h.f.harbo@medisin.uio.no
FAU - Riccio, M E
AU  - Riccio ME
FAU - Lorentzen, A R
AU  - Lorentzen AR
FAU - Utsi, E
AU  - Utsi E
FAU - Myhr, K-M
AU  - Myhr KM
FAU - Mellgren, S I
AU  - Mellgren SI
FAU - Flam, S T
AU  - Flam ST
FAU - Thorsby, E
AU  - Thorsby E
FAU - Sanchez-Mazas, A
AU  - Sanchez-Mazas A
FAU - Lie, B A
AU  - Lie BA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091230
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 9007-49-2 (DNA)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - DNA/genetics
MH  - Ethnicity/*genetics
MH  - Family
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Hypersensitivity/genetics
MH  - Leukocyte Common Antigens/genetics
MH  - Norway
MH  - White People/*genetics
EDAT- 2010/01/06 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/01/06 06:00
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - TAN1425 [pii]
AID - 10.1111/j.1399-0039.2009.01425.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Mar;75(3):207-17. doi: 10.1111/j.1399-0039.2009.01425.x. 
      Epub 2009 Dec 30.