PMID- 20049174
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-9112 (Electronic)
IS  - 1687-9104 (Print)
VI  - 2009
DP  - 2009
TI  - ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic 
      Leukemia.
PG  - 924301
LID - 10.1155/2009/924301 [doi]
LID - 924301
AB  - In this study, Forty-one out of fifty-seven Tunisian children with B-lineage 
      acute lymphoblastic leukemia (B-ALL), and without cytogenetically detectable 
      recurrent abnormalities at the time of the diagnosis, were evaluated by 
      fluorescence in situ hybridization (FISH) for the t(12;21). This translocation 
      leads ETV6-RUNX1 (previously TEL-AML1) fusion gene. 16 patients (28%) had 
      ETV6-RUNX1 rearrangement. In addition to this rearrangement, two cases showed a 
      loss of the normal ETV6 allele, and three others showed an extra signal of the 
      RUNX1 gene. Seven patients without ETV6-RUNX1 rearrangement showed extra signals 
      of the RUNX1 gene. One out of the 7 patients was also associated with a t(3;12) 
      identified by FISH. This is the first Tunisian study in which we report the 
      incidence of t(12;21) among childhood B-lineage ALL and in which we have found 
      multiple copies of RUNX1. Finally, our findings confirm that additional or 
      secondary genetic changes are commonly encountered in pediatric B-lineage ALL 
      with ETV6-RUNX1 gene fusion which is envisaged to play a pivotal role in disease 
      progression.
FAU - Gmidene, Abir
AU  - Gmidene A
AD  - Laboratoire de Cytogenetique et de Biologie de la Reproduction, CHU Farhat 
      Hached, Sousse 4000, Tunisia.
FAU - Elghezal, Hatem
AU  - Elghezal H
FAU - Sennana, Hlima
AU  - Sennana H
FAU - Ben Youssef, Yosra
AU  - Ben Youssef Y
FAU - Meddeb, Balkiss
AU  - Meddeb B
FAU - Elloumi, Moez
AU  - Elloumi M
FAU - Khlif, Abderrahim
AU  - Khlif A
FAU - Saad, Ali
AU  - Saad A
LA  - eng
PT  - Journal Article
DEP - 20091222
PL  - United States
TA  - Adv Hematol
JT  - Advances in hematology
JID - 101504271
PMC - PMC2799269
EDAT- 2010/01/06 06:00
MHDA- 2010/01/06 06:01
PMCR- 2009/12/22
CRDT- 2010/01/06 06:00
PHST- 2009/06/11 00:00 [received]
PHST- 2009/10/01 00:00 [revised]
PHST- 2009/11/14 00:00 [accepted]
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2010/01/06 06:01 [medline]
PHST- 2009/12/22 00:00 [pmc-release]
AID - 10.1155/2009/924301 [doi]
PST - ppublish
SO  - Adv Hematol. 2009;2009:924301. doi: 10.1155/2009/924301. Epub 2009 Dec 22.