PMID- 20049536
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20211020
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 26 Suppl 1
DP  - 2010 Feb
TI  - Prognostic value of late gadolinium enhancement in hypertensive patients with 
      known or suspected coronary artery disease.
PG  - 123-31
LID - 10.1007/s10554-009-9574-7 [doi]
AB  - To determine the prognosis of a myocardial scar assessed by a late gadolinium 
      enhancement (LGE) technique of cardiac magnetic resonance (CMR) in hypertensive 
      patients with known or suspected coronary artery disease (CAD). Patients with 
      systemic hypertension with known or suspected CAD without a clinical history of 
      myocardial infarction were enrolled. All patients underwent CMR for assessment of 
      cardiac function and LGE. Prognostic data was determined by the occurrence of a 
      hard cardiac endpoint, defined as cardiac death or a non-fatal myocardial 
      infarction, or major adverse cardiac events (MACEs), defined as cardiac death, a 
      non-fatal myocardial infarction, or hospitalization due to heart failure, 
      unstable angina, or life-threatening ventricular arrhythmia. A total of 1,644 
      patients were enrolled; 48% were males and the mean age was 65 +/- 11 years. The 
      average follow-up time was 863 +/- 559 days. Four hundred fifty-three (28%) 
      patients had LGE. LGE was the strongest and most independent predictor for hard 
      events and MACEs with hazard ratios of 4.77 and 3.38, respectively. Other 
      independent predictors of hard events and MACEs were left ventricular ejection 
      fraction and mass, the use of a beta-blocker, and a history of heart failure. The 
      risk of cardiac events increased as the extent of LGE increased; the hazard ratio 
      was 12.74 for hard events for those with a LGE >20% of the myocardium. LGE is the 
      most important and independent predictor for cardiac events in hypertensive 
      patients with known or suspected CAD.
FAU - Krittayaphong, Rungroj
AU  - Krittayaphong R
AD  - Division of Cardiology, Department of Medicine, Faculty of Medicine, Siriraj 
      Hospital, Mahidol University, Bangkok, 10700, Thailand. sirkt@mahidol.ac.th
FAU - Boonyasirinant, Thananya
AU  - Boonyasirinant T
FAU - Chaithiraphan, Vithaya
AU  - Chaithiraphan V
FAU - Maneesai, Adisak
AU  - Maneesai A
FAU - Saiviroonporn, Pairash
AU  - Saiviroonporn P
FAU - Nakyen, Supaporn
AU  - Nakyen S
FAU - Thanapiboonpol, Prajak
AU  - Thanapiboonpol P
FAU - Yindeengam, Ahthit
AU  - Yindeengam A
FAU - Udompanturak, Suthipol
AU  - Udompanturak S
LA  - eng
PT  - Journal Article
DEP - 20100105
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Chi-Square Distribution
MH  - *Contrast Media
MH  - Coronary Angiography
MH  - Coronary Artery Disease/etiology/mortality/*pathology
MH  - Female
MH  - *Gadolinium
MH  - Heart Diseases/*etiology/mortality/pathology
MH  - Humans
MH  - Hypertension/*complications/mortality/pathology
MH  - Kaplan-Meier Estimate
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
EDAT- 2010/01/06 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/01/06 06:00
PHST- 2009/10/17 00:00 [received]
PHST- 2009/12/18 00:00 [accepted]
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 10.1007/s10554-009-9574-7 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2010 Feb;26 Suppl 1:123-31. doi: 
      10.1007/s10554-009-9574-7. Epub 2010 Jan 5.