PMID- 20051294
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20180227
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 145
IP  - 2
DP  - 2010 Nov 19
TI  - High serum level of neopterin is a risk factor of patients with heart failure.
PG  - 318
LID - S0167-5273(09)01639-8 [pii]
LID - 10.1016/j.ijcard.2009.11.042 [doi]
AB  - Serum neopterin concentration was measured in 198 patients with chronic heart 
      failure (CHF) and 62 control subjects by ELISA. Patients were prospectively 
      followed during a median follow-up period of 745 days with end points of cardiac 
      death or re-hospitalization due to progressive heart failure. Serum concentration 
      of neopterin increased with advancing New York Heart Association (NYHA) 
      functional class (P<0.001). High neopterin group had a significantly higher 
      incidence of cardiac events than low neopterin group (P<0.0001). In the 
      multivariate Cox analysis, serum neopterin concentration was an independent risk 
      factor for cardiac events (hazard ratio 1.70, 95%CI 1.16-2.50, P=0.0068). Serum 
      neopterin concentration is a novel prognostic marker for CHF.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Sasaki, Toshiki
AU  - Sasaki T
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Takeishi, Yasuchika
AU  - Takeishi Y
AD  - Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, 
      Japan. Electronic address: takeishi@fmu.ac.jp.
FAU - Suzuki, Satoshi
AU  - Suzuki S
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Niizeki, Takeshi
AU  - Niizeki T
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Kitahara, Tatsuro
AU  - Kitahara T
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Katoh, Shigehiko
AU  - Katoh S
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Ishino, Mitsunori
AU  - Ishino M
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Shishido, Tetsuro
AU  - Shishido T
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Watanabe, Tetsu
AU  - Watanabe T
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Kubota, Isao
AU  - Kubota I
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Yamagata, Japan.
LA  - eng
PT  - Comparative Study
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20100106
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 670-65-5 (Neopterin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*blood/diagnosis/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Neopterin/biosynthesis/*blood
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2010/01/07 06:00
MHDA- 2011/10/05 06:00
CRDT- 2010/01/07 06:00
PHST- 2009/11/03 00:00 [received]
PHST- 2009/11/29 00:00 [accepted]
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - S0167-5273(09)01639-8 [pii]
AID - 10.1016/j.ijcard.2009.11.042 [doi]
PST - ppublish
SO  - Int J Cardiol. 2010 Nov 19;145(2):318. doi: 10.1016/j.ijcard.2009.11.042. Epub 
      2010 Jan 6.