PMID- 20051327
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20191210
IS  - 1878-562X (Electronic)
IS  - 1567-5394 (Linking)
VI  - 79
IP  - 1
DP  - 2010 Aug
TI  - Electrochemical oxidation of amphetamine-like drugs and application to 
      electroanalysis of ecstasy in human serum.
PG  - 77-83
LID - 10.1016/j.bioelechem.2009.12.002 [doi]
AB  - Amphetamine and amphetamine-like drugs are popular recreational drugs of abuse 
      because they are powerful stimulants of the central nervous system. Due to a 
      dramatic increase in the abuse of methylenedioxylated derivatives, individually 
      and/or in a mixture, and to the incoherent and contradictory interpretation of 
      the electrochemical data available on this subject, a comprehensive study of the 
      redox properties of amphetamine-like drugs was accomplished. The oxidative 
      behaviour of amphetamine (A), methamphetamine (MA), methylenedioxyamphetamine 
      (MDA) and methylenedioxymethamphetamine (MDMA) was studied in different buffer 
      systems by cyclic, differential pulse and square-wave voltammetry using a glassy 
      carbon electrode. A quantitative electroanalytical method was developed and 
      successfully applied to the determination of MDMA in seized samples and in human 
      serum. Validation parameters, such as sensitivity, precision and accuracy, were 
      evaluated. The results found using the developed electroanalytical methodology 
      enabled to gather some information about the content and amount of MDMA present 
      in ecstasy tablets found in Portugal. Moreover, the data found in this study 
      outlook the possibility of using the voltammetric methods to investigate the 
      potential harmful effects of interaction between drugs such as MDMA and 
      methamphetamine and other substances often used together in ecstasy tablets.
CI  - Copyright (c) 2009 Elsevier B.V. All rights reserved.
FAU - Garrido, E M P J
AU  - Garrido EM
AD  - Departamento de Engenharia Quimica, Instituto Superior de Engenharia do Porto, 
      IPP, Porto, Portugal.
FAU - Garrido, J M P J
AU  - Garrido JM
FAU - Milhazes, N
AU  - Milhazes N
FAU - Borges, F
AU  - Borges F
FAU - Oliveira-Brett, A M
AU  - Oliveira-Brett AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091211
PL  - Netherlands
TA  - Bioelectrochemistry
JT  - Bioelectrochemistry (Amsterdam, Netherlands)
JID - 100953583
RN  - 0 (Illicit Drugs)
RN  - 0 (Tablets)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Blood Chemical Analysis/*methods
MH  - Electrochemistry
MH  - Humans
MH  - Illicit Drugs/*blood/*chemistry
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*blood/*chemistry
MH  - Oxidation-Reduction
MH  - Tablets
EDAT- 2010/01/07 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/01/07 06:00
PHST- 2009/08/14 00:00 [received]
PHST- 2009/12/04 00:00 [revised]
PHST- 2009/12/05 00:00 [accepted]
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - S1567-5394(09)00218-7 [pii]
AID - 10.1016/j.bioelechem.2009.12.002 [doi]
PST - ppublish
SO  - Bioelectrochemistry. 2010 Aug;79(1):77-83. doi: 10.1016/j.bioelechem.2009.12.002. 
      Epub 2009 Dec 11.