PMID- 20051836
OWN - NLM
STAT- MEDLINE
DCOM- 20100309
LR  - 20181201
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 56
IP  - 1
DP  - 2010 Jan-Feb
TI  - Comparison between standard heparin and tinzaparin for haemodialysis catheter 
      lock.
PG  - 42-7
LID - 10.1097/MAT.0b013e3181c84e61 [doi]
AB  - Tinzaparin offers some advantages over unfractionated heparin (UFH) for 
      hemodialysis circuit anticoagulation. No study has compared these two molecules 
      as hemodialysis catheter locks. This study aimed to compare the efficacy of 
      tinzaparin and UFH as locks for hemodialysis tunnelled central venous catheter in 
      patients with end-stage renal disease (ESRD). A randomized, prospective, 
      single-blinded, controlled study was undertaken. Patients were randomly assigned 
      to receive UFH and tinzaparin for two 7-week periods in a crossover fashion. The 
      doses used were 5,000 U of UFH and 2,000 U of tinzaparin per catheter line. The 
      primary outcome was the need for thrombolytic catheter lock use defined with the 
      Hemodialysis Unit alteplase protocol. Forty-two patients with ESRD were enrolled, 
      totalling 815 UFH lock sessions and 729 tinzaparin lock sessions. A 47.4% 
      reduction in the incidence of alteplase lock use was observed with tinzaparin 
      lock (3.16% vs. 6.01%, chi-square, p = 0.0078). There was no significant 
      difference in the time to first alteplase use between the two locks by 
      Kaplan-Meier survival analysis (logrank, p = 0.0900). Our results suggest that 
      tinzaparin could be an appropriate alternative for a hemodialysis tunnelled 
      central venous catheter lock, but these results should be confirmed with a larger 
      trial.
FAU - Malo, Josianne
AU  - Malo J
AD  - Pharmacy Department, CHU Sainte-Justine, Montreal, Quebec, Canada. 
      josianne_malo@ssss.gouv.qc.ca
FAU - Jolicoeur, Carine
AU  - Jolicoeur C
FAU - Theriault, Fannie
AU  - Theriault F
FAU - Lachaine, Jean
AU  - Lachaine J
FAU - Senecal, Lynne
AU  - Senecal L
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 7UQ7X4Y489 (Tinzaparin)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Aged
MH  - Catheterization, Central Venous/*methods
MH  - Cross-Over Studies
MH  - Female
MH  - Fibrinolytic Agents/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Male
MH  - Renal Dialysis/*methods
MH  - Tinzaparin
MH  - Tissue Plasminogen Activator
EDAT- 2010/01/07 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/01/07 06:00
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 10.1097/MAT.0b013e3181c84e61 [doi]
PST - ppublish
SO  - ASAIO J. 2010 Jan-Feb;56(1):42-7. doi: 10.1097/MAT.0b013e3181c84e61.