PMID- 20052590
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20211020
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 267
IP  - 7
DP  - 2010 Jul
TI  - Laryngeal carcinoma lymph node metastasis and disease-free survival correlate 
      with MASPIN nuclear expression but not with EGFR expression: a series of 108 
      cases.
PG  - 1103-10
LID - 10.1007/s00405-009-1186-2 [doi]
AB  - Despite advances in laryngeal squamous cell carcinoma (LSCC) treatment, patient 
      survival has not improved in the last two decades. Novel, more effective 
      strategies should be based on receptor-mediated LSCC-targeted therapy. The 
      epidermal growth factor receptor (EGFR) is the most widely studied molecular 
      target. MASPIN multifaceted anti-tumor effects have been rarely evaluated in 
      LSCC. The aims of this study were to investigate EGFR and MASPIN expression and 
      the role of sub-cellular MASPIN localization in LSSC. MASPIN and EGFR expression 
      and the sub-cellular localization of MASPIN were assessed using a computerized 
      image analysis system in 108 consecutive cases of operable LSCC. The rates of 
      occurrence of lymph node metastases and recurrent disease were lower in patients 
      with a nuclear pattern of MASPIN expression (p = 0.004, p = 0.0028). As expected, 
      the loco-regional recurrence rate was lower in N0 patients (p = 0.009), but the 
      disease recurrence rate was even lower in N0 patients with a nuclear localization 
      of MASPIN (p = 0.020). Disease-free survival was longer in cases of LSCC with a 
      nuclear MASPIN pattern (p = 0.003). The intensity of EGFR reactivity and the EGFR 
      area fraction were unrelated to the clinico-pathological and prognostic 
      parameters in LSCC. A nuclear MASPIN pattern is a promising prognostic indicator 
      in LSCC, but further evidence is needed before elective neck dissection can be 
      considered for cN0 LSCCs with a non-nuclear MASPIN pattern. Although a better 
      understanding of the mechanisms behind sub-cellular MASPIN localization is 
      mandatory, re-activating nuclear MASPIN in association with specific 
      chemotherapeutic agents may be an important goal in the treatment of LSCC.
FAU - Marioni, Gino
AU  - Marioni G
AD  - Otolaryngology Section, Department of Medical and Surgical Specialties, 
      University of Padova, Via Giustiniani 2, 35128 Padua, Italy. 
      gino.marioni@unipd.it
FAU - Staffieri, Alberto
AU  - Staffieri A
FAU - Bertolin, Andy
AU  - Bertolin A
FAU - Giacomelli, Luciano
AU  - Giacomelli L
FAU - D'Alessandro, Emiliano
AU  - D'Alessandro E
FAU - Ottaviano, Giancarlo
AU  - Ottaviano G
FAU - Accordi, Daria
AU  - Accordi D
FAU - Stramare, Roberto
AU  - Stramare R
FAU - de Filippis, Cosimo
AU  - de Filippis C
FAU - Blandamura, Stella
AU  - Blandamura S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100106
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (SERPIN-B5)
RN  - 0 (Serpins)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Analysis of Variance
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Chi-Square Distribution
MH  - Diagnostic Imaging
MH  - Disease-Free Survival
MH  - ErbB Receptors/*metabolism
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Laryngectomy
MH  - Laryngoscopy
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Serpins/*metabolism
EDAT- 2010/01/07 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/01/07 06:00
PHST- 2009/09/27 00:00 [received]
PHST- 2009/12/16 00:00 [accepted]
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.1007/s00405-009-1186-2 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2010 Jul;267(7):1103-10. doi: 
      10.1007/s00405-009-1186-2. Epub 2010 Jan 6.