PMID- 20052914
OWN - NLM
STAT- MEDLINE
DCOM- 20100122
LR  - 20201209
IS  - 0235-2990 (Print)
IS  - 0235-2990 (Linking)
VI  - 54
IP  - 5-6
DP  - 2009
TI  - [Impact of liposomes and ceftriaxone-entrapped liposomes on skin wound healing in 
      rats].
PG  - 25-30
AB  - "Empty" liposomes and ceftriaxone (CT)-entrapped liposomes were developed. Lipids 
      of natural origin, i. e. soybean phosphatidyl choline (PhCh) and cholesterol were 
      used for the design. The conditions for production of the CT-entrapped liposomes 
      were optimized to provide the maximum content of the antibiotic in the liposomes. 
      The effect of the "empty" liposomes and the antibiotic-entrapped liposomes on 
      healing of skin wounds was studied on rats. The wound on the skin surface of the 
      rat back was purulent due to contamination with E. coli (10(9) cells/ml). The 
      treatment with the antibiotic solution, "empty" liposomes or CT-entrapped 
      liposomes was started in 48 hours. The use of the PhCh "empty" liposomes promoted 
      more rapid healing of the wound vs. the control or the treatment with CT aqueous 
      solution. The treatmen of the wound with the CT-entrapped PhCh liposomes provided 
      2 times more rapid healing vs. the control or the use of the CT aqueous solution.
FAU - Kurilko, N L
AU  - Kurilko NL
FAU - Kiiamov, A K
AU  - Kiiamov AK
FAU - Ivanova, M A
AU  - Ivanova MA
FAU - Pashkov, E P
AU  - Pashkov EP
FAU - Aleksandrov, M T
AU  - Aleksandrov MT
FAU - Sorokoumova, G M
AU  - Sorokoumova GM
FAU - Shvets, V I
AU  - Shvets VI
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Antibiot Khimioter
JT  - Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]
JID - 8803688
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Liposomes)
RN  - 75J73V1629 (Ceftriaxone)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Ceftriaxone/*pharmacology
MH  - *Escherichia coli
MH  - Escherichia coli Infections/*drug therapy
MH  - Liposomes
MH  - Rats
MH  - Skin/*injuries/microbiology
MH  - Wound Healing/*drug effects
MH  - Wound Infection/*drug therapy
MH  - Wounds, Penetrating/*drug therapy/microbiology
EDAT- 2010/01/08 06:00
MHDA- 2010/01/23 06:00
CRDT- 2010/01/08 06:00
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/01/23 06:00 [medline]
PST - ppublish
SO  - Antibiot Khimioter. 2009;54(5-6):25-30.