PMID- 20053141
OWN - NLM
STAT- MEDLINE
DCOM- 20100528
LR  - 20211020
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 15
IP  - 5-6
DP  - 2009 Sep
TI  - Chlamydia pneumoniae-specific intrathecal oligoclonal antibody response is 
      predominantly detected in a subset of multiple sclerosis patients with 
      progressive forms.
PG  - 425-33
LID - 10.3109/13550280903475580 [doi]
AB  - The purpose of this study was to verify the actual involvement of Chlamydia 
      pneumoniae in multiple sclerosis (MS) by the evaluation of its specific 
      intrathecal humoral immune response in MS. We measured by enzyme-linked 
      immunosorbent assay (ELISA) technique cerebrospinal fluid (CSF) and serum levels 
      of anti-C. pneumoniae immunoglobulin G (IgG) in 27 relapsing-remitting (RR), 9 
      secondary progressive (SP), and 5 primary progressive (PP) MS patients, grouped 
      according to clinical and magnetic resonance imaging (MRI) evidence of disease 
      activity. Twenty-one patients with other inflammatory neurological disorders 
      (OIND) and 21 with noninflammatory neurological disorders (NIND) were used as 
      controls. Quantitative intrathecal synthesis of anti-C. pneumoniae IgG was 
      determined by antibody-specific index (ASI), whereas the presence of C. 
      pneumoniae-specific CSF oligoclonal IgG bands was assessed by antigen-specific 
      immunoblotting. ASI values indicative of C. pneumoniae-specific intrathecal IgG 
      synthesis were present in a small proportion of MS (29.3%), OIND (33.3%), and 
      NIND (4.8%) patients and were significantly more frequent (P < .05) in total MS 
      and in OIND than in NIND and in SP (P < .01) and PP MS (P < .05) than in RR MS. 
      C. pneumoniae-specific CSF-restricted OCB were detected only in three SP, one PP, 
      and one RR MS patients. These findings suggest that an intrathecal production of 
      anti-C. pneumoniae IgG is part of humoral polyreactivity driven by MS chronic 
      brain inflammation. However, an intrathecal release of C. pneumoniae-specific 
      oligoclonal IgG can occur in a subset of patients with MS progressive forms in 
      whom a C. pneumoniae-persistent brain infection may play a pathogenetic role.
FAU - Fainardi, Enrico
AU  - Fainardi E
AD  - Neuroradiology Unit, Department of Neurosciences and Rehabilitation, Azienda 
      Ospedaliera-Universitaria, Arcispedale S. Anna, Ferrara, Italy. henryfai@tin.it
FAU - Castellazzi, Massimiliano
AU  - Castellazzi M
FAU - Tamborino, Carmine
AU  - Tamborino C
FAU - Seraceni, Silva
AU  - Seraceni S
FAU - Tola, Maria Rosaria
AU  - Tola MR
FAU - Granieri, Enrico
AU  - Granieri E
FAU - Contini, Carlo
AU  - Contini C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Oligoclonal Bands)
SB  - IM
MH  - Adult
MH  - Antibodies, Bacterial/blood/cerebrospinal fluid/immunology
MH  - Antibody Specificity
MH  - Chlamydophila Infections/*complications/*immunology
MH  - Chlamydophila pneumoniae/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Chronic Progressive/*complications/*immunology/pathology
MH  - Oligoclonal Bands/blood/cerebrospinal fluid/*immunology
EDAT- 2010/01/08 06:00
MHDA- 2010/05/29 06:00
CRDT- 2010/01/08 06:00
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/05/29 06:00 [medline]
AID - 10.3109/13550280903475580 [doi]
PST - ppublish
SO  - J Neurovirol. 2009 Sep;15(5-6):425-33. doi: 10.3109/13550280903475580.