PMID- 20056213
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20220321
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 94
IP  - 5
DP  - 2010 Oct
TI  - Clinical and prognostic significance of human papillomavirus DNA in the sperm or 
      exfoliated cells of infertile patients and subjects with risk factors.
PG  - 1723-7
LID - 10.1016/j.fertnstert.2009.11.012 [doi]
AB  - OBJECTIVE: To evaluate human papillomavirus (HPV) sperm infection and its 
      correlation with sperm parameters in infertile patients and subjects with risk 
      factors. DESIGN: Cross-sectional clinical study. SETTING: Andrology and 
      microbiology sections at a university hospital. PATIENT(S): A cohort of 290 
      subjects: 26 with genital warts, 66 with HPV positive partners, 108 infertile 
      patients, and 90 fertile controls. INTERVENTION(S): Semen analysis, sperm 
      culture, polymerase chain reaction, and fluorescence in situ hybridization (FISH) 
      for HPV detection. Statistical analysis was performed with a two-tailed Student's 
      t-test. RESULT(S): The prevalence of HPV semen infection found in all groups was 
      as follows: patients with genital warts, 53.8%; infected partners, 40.9%; 
      infertile patients, 10.2%, fertile controls, 2.2%. Infertile patients had a 
      higher HPV DNA prevalence in sperm cells than the other groups. The results of 
      HPV investigation were compared with sperm parameters and the results of FISH 
      analysis. Sperm motility was more frequently reduced in infected samples and in 
      particular when the infection was present in the sperm. CONCLUSION(S): This study 
      demonstrated a very high prevalence of infection in the semen of patients with 
      risk factors for HPV. In each group of subjects, HPV seems to be preferentially 
      located in sperm or exfoliated cells, with different effects on sperm motility.
CI  - Copyright (c) 2010 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Foresta, Carlo
AU  - Foresta C
AD  - Department of Histology, Microbiology, and Medical Biotechnologies, Section of 
      Clinical Pathology and Centre for Male Gamete Cryopreservation, University of 
      Padova, Italy. carlo.foresta@unipd.it
FAU - Pizzol, Damiano
AU  - Pizzol D
FAU - Moretti, Afra
AU  - Moretti A
FAU - Barzon, Luisa
AU  - Barzon L
FAU - Palu, Giorgio
AU  - Palu G
FAU - Garolla, Andrea
AU  - Garolla A
LA  - eng
PT  - Journal Article
DEP - 20100113
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - DNA, Viral/*analysis
MH  - Humans
MH  - Infertility, Male/diagnosis/*epidemiology/virology
MH  - Male
MH  - Papillomaviridae/*genetics/isolation & purification
MH  - Papillomavirus Infections/complications/diagnosis/*epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Risk Factors
MH  - Semen Analysis
MH  - Sperm Motility
MH  - Spermatozoa/*virology
EDAT- 2010/01/09 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/01/09 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2009/11/03 00:00 [revised]
PHST- 2009/11/04 00:00 [accepted]
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - S0015-0282(09)04041-2 [pii]
AID - 10.1016/j.fertnstert.2009.11.012 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Oct;94(5):1723-7. doi: 10.1016/j.fertnstert.2009.11.012. Epub 
      2010 Jan 13.