PMID- 20057128
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20131121
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 74
IP  - 1
DP  - 2010
TI  - Effects of single and combined administration of fermented barley extract and 
      gamma-aminobutyric acid on the development of atopic dermatitis in NC/Nga mice.
PG  - 135-9
AB  - We examined the effects single and combined administration of fermented barley 
      extract P (FBEP), prepared from barley-shochu distillery by-products, and 
      gamma-aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like 
      skin lesions in NC/Nga mice. Single administration of FBEP and GABA 
      dose-dependently reduced the development of AD-like skin lesions in mice. GABA 
      reduced the development of AD-like skin lesions by suppressing serum 
      immunoglobulin E (IgE) and splenocyte interleukin (IL)-4 production, while FBEP 
      reduced skin lesions without affecting the IgE or cytokine production. However, 
      in mice with induced AD-like skin lesions, combined administration of FBEP and 
      GABA decreased serum IgE levels and splenic cell IL-4 production, and increased 
      splenic cell interferon-gamma production. These results suggest that combined 
      administration of FBEP and GABA alleviated AD-like skin lesions in the NC/Nga 
      mice by adjusting the Th1/Th2 balance to a Th1-predominant immune response.
FAU - Hokazono, Hideki
AU  - Hokazono H
AD  - Research Laboratory, Sanwa Shurui Co., Ltd., Usa, Oita, Japan. 
      hokazono-h@kokuzo.co.jp
FAU - Omori, Toshiro
AU  - Omori T
FAU - Ono, Kazuhisa
AU  - Ono K
LA  - eng
PT  - Journal Article
DEP - 20100107
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - Z4ZG7O5SZ9 (Picryl Chloride)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cytokines/metabolism
MH  - Dermatitis, Atopic/blood/chemically induced/physiopathology/*prevention & control
MH  - Female
MH  - *Fermentation
MH  - Hordeum/*chemistry/metabolism
MH  - Immunoglobulin E/blood
MH  - Mice
MH  - Picryl Chloride/administration & dosage/pharmacology
MH  - Plant Extracts/*administration & dosage/metabolism/*pharmacology
MH  - gamma-Aminobutyric Acid/*administration & dosage/*pharmacology
EDAT- 2010/01/09 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/01/09 06:00
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - JST.JSTAGE/bbb/90653 [pii]
AID - 10.1271/bbb.90653 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2010;74(1):135-9. doi: 10.1271/bbb.90653. Epub 2010 
      Jan 7.